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The glutathione transferase Mu null genotype leads to lower 6-MMPR levels in patients treated with azathioprine but not with mercaptopurine.
Broekman MMTJ, Wong DR, Wanten GJA, Roelofs HM, van Marrewijk CJ, Klungel OH, Verbeek ALM, Hooymans PM, Guchelaar HJ, Scheffer H, Derijks LJJ, Coenen MJH, de Jong DJ. Broekman MMTJ, et al. Among authors: wong dr. Pharmacogenomics J. 2018 Jan;18(1):160-166. doi: 10.1038/tpj.2016.87. Epub 2017 Jan 3. Pharmacogenomics J. 2018. PMID: 28045129
Dose-dependent influence of 5-aminosalicylates on thiopurine metabolism.
de Boer NK, Wong DR, Jharap B, de Graaf P, Hooymans PM, Mulder CJ, Rijmen F, Engels LG, van Bodegraven AA. de Boer NK, et al. Among authors: wong dr. Am J Gastroenterol. 2007 Dec;102(12):2747-53. doi: 10.1111/j.1572-0241.2007.01511.x. Epub 2007 Aug 31. Am J Gastroenterol. 2007. PMID: 17764493
Influence of 5-aminosalicylic acid on 6-thioguanosine phosphate metabolite levels: a prospective study in patients under steady thiopurine therapy.
de Graaf P, de Boer NK, Wong DR, Karner S, Jharap B, Hooymans PM, Veldkamp AI, Mulder CJ, van Bodegraven AA, Schwab M. de Graaf P, et al. Among authors: wong dr. Br J Pharmacol. 2010 Jul;160(5):1083-91. doi: 10.1111/j.1476-5381.2010.00731.x. Br J Pharmacol. 2010. PMID: 20590602 Free PMC article. Clinical Trial.
Therapeutic drug monitoring of thiopurine metabolites in adult thiopurine tolerant IBD patients on maintenance therapy.
Gilissen LP, Wong DR, Engels LG, Bierau J, Bakker JA, Paulussen AD, Romberg-Camps MJ, Stronkhorst A, Bus P, Bos LP, Hooymans PM, Stockbrügger RW, Neef C, Masclee AA. Gilissen LP, et al. Among authors: wong dr. J Crohns Colitis. 2012 Jul;6(6):698-707. doi: 10.1016/j.crohns.2011.12.003. Epub 2012 Jan 10. J Crohns Colitis. 2012. PMID: 22398098 Clinical Trial.
Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease.
Coenen MJ, de Jong DJ, van Marrewijk CJ, Derijks LJ, Vermeulen SH, Wong DR, Klungel OH, Verbeek AL, Hooymans PM, Peters WH, te Morsche RH, Newman WG, Scheffer H, Guchelaar HJ, Franke B; TOPIC Recruitment Team. Coenen MJ, et al. Among authors: wong dr. Gastroenterology. 2015 Oct;149(4):907-17.e7. doi: 10.1053/j.gastro.2015.06.002. Epub 2015 Jun 11. Gastroenterology. 2015. PMID: 26072396 Clinical Trial.
77 results