Piekarz AD - Search Results

1

Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.

Flinspach M, Xu Q, Piekarz AD, Fellows R, Hagan R, Gibbs A, Liu Y, Neff RA, Freedman J, Eckert WA, Zhou M, Bonesteel R, Pennington MW, Eddinger KA, Yaksh TL, Hunter M, Swanson RV, Wickenden AD. Flinspach M, et al. Among authors: piekarz ad. Sci Rep. 2017 Jan 3;7:39662. doi: 10.1038/srep39662. Sci Rep. 2017. PMID: 28045073 Free PMC article.

2

Characterisation of Nav1.7 functional expression in rat dorsal root ganglia neurons by using an electrical field stimulation assay.

Fouillet A, Watson JF, Piekarz AD, Huang X, Li B, Priest B, Nisenbaum E, Sher E, Ursu D. Fouillet A, et al. Among authors: piekarz ad. Mol Pain. 2017 Jan-Dec;13:1744806917745179. doi: 10.1177/1744806917745179. Epub 2017 Nov 22. Mol Pain. 2017. PMID: 29166836 Free PMC article.

3

Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navbeta4 peptide-mediated resurgent sodium currents.

Theile JW, Jarecki BW, Piekarz AD, Cummins TR. Theile JW, et al. Among authors: piekarz ad. J Physiol. 2011 Feb 1;589(Pt 3):597-608. doi: 10.1113/jphysiol.2010.200915. Epub 2010 Nov 29. J Physiol. 2011. PMID: 21115638 Free PMC article.

4

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.

Jarecki BW, Piekarz AD, Jackson JO 2nd, Cummins TR. Jarecki BW, et al. Among authors: piekarz ad. J Clin Invest. 2010 Jan;120(1):369-78. doi: 10.1172/JCI40801. Epub 2009 Dec 28. J Clin Invest. 2010. PMID: 20038812 Free PMC article.

5

Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators.

Tan ZY, Piekarz AD, Priest BT, Knopp KL, Krajewski JL, McDermott JS, Nisenbaum ES, Cummins TR. Tan ZY, et al. Among authors: piekarz ad. J Neurosci. 2014 May 21;34(21):7190-7. doi: 10.1523/JNEUROSCI.5011-13.2014. J Neurosci. 2014. PMID: 24849353 Free PMC article.

6

CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy.

Piekarz AD, Due MR, Khanna M, Wang B, Ripsch MS, Wang R, Meroueh SO, Vasko MR, White FA, Khanna R. Piekarz AD, et al. Mol Pain. 2012 Jul 24;8:54. doi: 10.1186/1744-8069-8-54. Mol Pain. 2012. PMID: 22828369 Free PMC article.

7

The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity.

Song W, Xiao Y, Chen H, Ashpole NM, Piekarz AD, Ma P, Hudmon A, Cummins TR, Shou W. Song W, et al. Among authors: piekarz ad. J Physiol. 2012 Oct 15;590(20):5123-39. doi: 10.1113/jphysiol.2012.235374. Epub 2012 Jul 23. J Physiol. 2012. PMID: 22826127 Free PMC article.

8

An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels.

Brittain JM, Piekarz AD, Wang Y, Kondo T, Cummins TR, Khanna R. Brittain JM, et al. Among authors: piekarz ad. J Biol Chem. 2009 Nov 6;284(45):31375-90. doi: 10.1074/jbc.M109.009951. Epub 2009 Sep 15. J Biol Chem. 2009. PMID: 19755421 Free PMC article.

9

Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex.

Wilson SM, Brittain JM, Piekarz AD, Ballard CJ, Ripsch MS, Cummins TR, Hurley JH, Khanna M, Hammes NM, Samuels BC, White FA, Khanna R. Wilson SM, et al. Among authors: piekarz ad. Channels (Austin). 2011 Sep-Oct;5(5):449-56. doi: 10.4161/chan.5.5.17363. Epub 2011 Sep 1. Channels (Austin). 2011. PMID: 21829088 Free PMC article.

10

Identification of the benzyloxyphenyl pharmacophore: a structural unit that promotes sodium channel slow inactivation.

King AM, Yang XF, Wang Y, Dustrude ET, Barbosa C, Due MR, Piekarz AD, Wilson SM, White FA, Salomé C, Cummins TR, Khanna R, Kohn H. King AM, et al. Among authors: piekarz ad. ACS Chem Neurosci. 2012 Dec 19;3(12):1037-49. doi: 10.1021/cn300129d. Epub 2012 Sep 19. ACS Chem Neurosci. 2012. PMID: 23259039 Free PMC article.

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