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73 results

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Page 1
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen.
Cheeseman MD, Chessum NE, Rye CS, Pasqua AE, Tucker MJ, Wilding B, Evans LE, Lepri S, Richards M, Sharp SY, Ali S, Rowlands M, O'Fee L, Miah A, Hayes A, Henley AT, Powers M, Te Poele R, De Billy E, Pellegrino L, Raynaud F, Burke R, van Montfort RL, Eccles SA, Workman P, Jones K. Cheeseman MD, et al. Among authors: van montfort rl. J Med Chem. 2017 Jan 12;60(1):180-201. doi: 10.1021/acs.jmedchem.6b01055. Epub 2016 Dec 22. J Med Chem. 2017. PMID: 28004573 Free PMC article.
Structure-based design of molecular cancer therapeutics.
van Montfort RL, Workman P. van Montfort RL, et al. Trends Biotechnol. 2009 May;27(5):315-28. doi: 10.1016/j.tibtech.2009.02.003. Epub 2009 Mar 30. Trends Biotechnol. 2009. PMID: 19339067 Review.
Identification of inhibitors of checkpoint kinase 1 through template screening.
Matthews TP, Klair S, Burns S, Boxall K, Cherry M, Fisher M, Westwood IM, Walton MI, McHardy T, Cheung KM, Van Montfort R, Williams D, Aherne GW, Garrett MD, Reader J, Collins I. Matthews TP, et al. J Med Chem. 2009 Aug 13;52(15):4810-9. doi: 10.1021/jm900314j. J Med Chem. 2009. PMID: 19572549
PI(3) kinases: revealing the delta lady.
Workman P, van Montfort RL. Workman P, et al. Among authors: van montfort rl. Nat Chem Biol. 2010 Feb;6(2):82-3. doi: 10.1038/nchembio.305. Nat Chem Biol. 2010. PMID: 20081818 No abstract available.
Drugging the PI3 kinome: from chemical tools to drugs in the clinic.
Workman P, Clarke PA, Raynaud FI, van Montfort RL. Workman P, et al. Among authors: van montfort rl. Cancer Res. 2010 Mar 15;70(6):2146-57. doi: 10.1158/0008-5472.CAN-09-4355. Epub 2010 Feb 23. Cancer Res. 2010. PMID: 20179189 Free PMC article. Review.
Unveiling the secrets of the ancestral PI3 kinase Vps34.
Workman P, van Montfort RL. Workman P, et al. Among authors: van montfort rl. Cancer Cell. 2010 May 18;17(5):421-3. doi: 10.1016/j.ccr.2010.04.016. Cancer Cell. 2010. PMID: 20478524 Free article.
Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization.
Whelligan DK, Solanki S, Taylor D, Thomson DW, Cheung KM, Boxall K, Mas-Droux C, Barillari C, Burns S, Grummitt CG, Collins I, van Montfort RL, Aherne GW, Bayliss R, Hoelder S. Whelligan DK, et al. Among authors: van montfort rl. J Med Chem. 2010 Nov 11;53(21):7682-98. doi: 10.1021/jm1008727. J Med Chem. 2010. PMID: 20936789 Free PMC article.
Benzimidazole inhibitors induce a DFG-out conformation of never in mitosis gene A-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure-activity relationship.
Solanki S, Innocenti P, Mas-Droux C, Boxall K, Barillari C, van Montfort RL, Aherne GW, Bayliss R, Hoelder S. Solanki S, et al. Among authors: van montfort rl. J Med Chem. 2011 Mar 24;54(6):1626-39. doi: 10.1021/jm1011726. Epub 2011 Mar 2. J Med Chem. 2011. PMID: 21366329
73 results