Sharp SY - Search Results

1

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen.

Cheeseman MD, Chessum NE, Rye CS, Pasqua AE, Tucker MJ, Wilding B, Evans LE, Lepri S, Richards M, Sharp SY, Ali S, Rowlands M, O'Fee L, Miah A, Hayes A, Henley AT, Powers M, Te Poele R, De Billy E, Pellegrino L, Raynaud F, Burke R, van Montfort RL, Eccles SA, Workman P, Jones K. Cheeseman MD, et al. Among authors: sharp sy. J Med Chem. 2017 Jan 12;60(1):180-201. doi: 10.1021/acs.jmedchem.6b01055. Epub 2016 Dec 22. J Med Chem. 2017. PMID: 28004573 Free PMC article.

2

Effects of a new antioestrogen, idoxifene, on cisplatin- and doxorubicin-sensitive and -resistant human ovarian carcinoma cell lines.

Sharp SY, Rowlands MG, Jarman M, Kelland LR. Sharp SY, et al. Br J Cancer. 1994 Sep;70(3):409-14. doi: 10.1038/bjc.1994.319. Br J Cancer. 1994. PMID: 8080723 Free PMC article.

3

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90.

Kelland LR, Sharp SY, Rogers PM, Myers TG, Workman P. Kelland LR, et al. Among authors: sharp sy. J Natl Cancer Inst. 1999 Nov 17;91(22):1940-9. doi: 10.1093/jnci/91.22.1940. J Natl Cancer Inst. 1999. PMID: 10564678

4

Mini-review: discovery and development of platinum complexes designed to circumvent cisplatin resistance.

Kelland LR, Sharp SY, O'Neill CF, Raynaud FI, Beale PJ, Judson IR. Kelland LR, et al. Among authors: sharp sy. J Inorg Biochem. 1999 Oct;77(1-2):111-5. J Inorg Biochem. 1999. PMID: 10626362 Review.

5

Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo.

Sharp SY, Kelland LR, Valenti MR, Brunton LA, Hobbs S, Workman P. Sharp SY, et al. Mol Pharmacol. 2000 Nov;58(5):1146-55. doi: 10.1124/mol.58.5.1146. Mol Pharmacol. 2000. PMID: 11040064

6

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.

Cheung KM, Matthews TP, James K, Rowlands MG, Boxall KJ, Sharp SY, Maloney A, Roe SM, Prodromou C, Pearl LH, Aherne GW, McDonald E, Workman P. Cheung KM, et al. Among authors: sharp sy. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3338-43. doi: 10.1016/j.bmcl.2005.05.046. Bioorg Med Chem Lett. 2005. PMID: 15955698

7

Solid-phase immunoassays in mechanism-based drug discovery: their application in the development of inhibitors of the molecular chaperone heat-shock protein 90.

Hardcastle A, Boxall K, Richards J, Tomlin P, Sharp S, Clarke P, Workman P, Aherne W. Hardcastle A, et al. Assay Drug Dev Technol. 2005 Jun;3(3):273-85. doi: 10.1089/adt.2005.3.273. Assay Drug Dev Technol. 2005. PMID: 15971989

8

Inhibitors of the HSP90 molecular chaperone: current status.

Sharp S, Workman P. Sharp S, et al. Adv Cancer Res. 2006;95:323-48. doi: 10.1016/S0065-230X(06)95009-X. Adv Cancer Res. 2006. PMID: 16860662 Review.

9

Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol.

Proisy N, Sharp SY, Boxall K, Connelly S, Roe SM, Prodromou C, Slawin AM, Pearl LH, Workman P, Moody CJ. Proisy N, et al. Among authors: sharp sy. Chem Biol. 2006 Nov;13(11):1203-15. doi: 10.1016/j.chembiol.2006.09.015. Chem Biol. 2006. PMID: 17114002

10

In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.

Sharp SY, Boxall K, Rowlands M, Prodromou C, Roe SM, Maloney A, Powers M, Clarke PA, Box G, Sanderson S, Patterson L, Matthews TP, Cheung KM, Ball K, Hayes A, Raynaud F, Marais R, Pearl L, Eccles S, Aherne W, McDonald E, Workman P. Sharp SY, et al. Cancer Res. 2007 Mar 1;67(5):2206-16. doi: 10.1158/0008-5472.CAN-06-3473. Cancer Res. 2007. PMID: 17332351 Free article.

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