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Page 1
PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis.
Mukhopadhyay P, Horváth B, Rajesh M, Varga ZV, Gariani K, Ryu D, Cao Z, Holovac E, Park O, Zhou Z, Xu MJ, Wang W, Godlewski G, Paloczi J, Nemeth BT, Persidsky Y, Liaudet L, Haskó G, Bai P, Boulares AH, Auwerx J, Gao B, Pacher P. Mukhopadhyay P, et al. Among authors: auwerx j. J Hepatol. 2017 Mar;66(3):589-600. doi: 10.1016/j.jhep.2016.10.023. Epub 2016 Oct 29. J Hepatol. 2017. PMID: 27984176
PARP-2 regulates SIRT1 expression and whole-body energy expenditure.
Bai P, Canto C, Brunyánszki A, Huber A, Szántó M, Cen Y, Yamamoto H, Houten SM, Kiss B, Oudart H, Gergely P, Menissier-de Murcia J, Schreiber V, Sauve AA, Auwerx J. Bai P, et al. Among authors: auwerx j. Cell Metab. 2011 Apr 6;13(4):450-460. doi: 10.1016/j.cmet.2011.03.013. Cell Metab. 2011. PMID: 21459329 Free PMC article.
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.
Bai P, Cantó C, Oudart H, Brunyánszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper RH, Schoonjans K, Schreiber V, Sauve AA, Menissier-de Murcia J, Auwerx J. Bai P, et al. Among authors: auwerx j. Cell Metab. 2011 Apr 6;13(4):461-468. doi: 10.1016/j.cmet.2011.03.004. Cell Metab. 2011. PMID: 21459330 Free PMC article.
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.
Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J. Cantó C, et al. Among authors: auwerx j. Cell Metab. 2012 Jun 6;15(6):838-47. doi: 10.1016/j.cmet.2012.04.022. Cell Metab. 2012. PMID: 22682224 Free PMC article.
Mitonuclear protein imbalance as a conserved longevity mechanism.
Houtkooper RH, Mouchiroud L, Ryu D, Moullan N, Katsyuba E, Knott G, Williams RW, Auwerx J. Houtkooper RH, et al. Among authors: auwerx j. Nature. 2013 May 23;497(7450):451-7. doi: 10.1038/nature12188. Nature. 2013. PMID: 23698443 Free PMC article.
Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis.
Verbeek J, Lannoo M, Pirinen E, Ryu D, Spincemaille P, Vander Elst I, Windmolders P, Thevissen K, Cammue BP, van Pelt J, Fransis S, Van Eyken P, Ceuterick-De Groote C, Van Veldhoven PP, Bedossa P, Nevens F, Auwerx J, Cassiman D. Verbeek J, et al. Among authors: auwerx j. Gut. 2015 Apr;64(4):673-83. doi: 10.1136/gutjnl-2014-306748. Epub 2014 Jun 10. Gut. 2015. PMID: 24917551
635 results