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A phase I clinical and pharmacokinetic study of the multi-drug resistance protein-1 (MRP-1) inhibitor sulindac, in combination with epirubicin in patients with advanced cancer.
O'Connor R, O'Leary M, Ballot J, Collins CD, Kinsella P, Mager DE, Arnold RD, O'Driscoll L, Larkin A, Kennedy S, Fennelly D, Clynes M, Crown J. O'Connor R, et al. Cancer Chemother Pharmacol. 2007 Jan;59(1):79-87. doi: 10.1007/s00280-006-0240-7. Epub 2006 Apr 27. Cancer Chemother Pharmacol. 2007. PMID: 16642371 Clinical Trial.
A novel inhibitory anti-invasive MAb isolated using phenotypic screening highlights AnxA6 as a functionally relevant target protein in pancreatic cancer.
O'Sullivan D, Dowling P, Joyce H, McAuley E, McCann A, Henry M, McGovern B, Barham P, Kelleher FC, Murphy J, Kennedy S, Swan N, Moriarty M, Clynes M, Larkin A. O'Sullivan D, et al. Br J Cancer. 2017 Oct 24;117(9):1326-1335. doi: 10.1038/bjc.2017.306. Epub 2017 Sep 7. Br J Cancer. 2017. PMID: 28881357 Free PMC article.
Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer.
Dowling P, Hughes DJ, Larkin AM, Meiller J, Henry M, Meleady P, Lynch V, Pardini B, Naccarati A, Levy M, Vodicka P, Neary P, Clynes M. Dowling P, et al. Among authors: larkin am. Clin Chim Acta. 2015 Feb 20;441:133-41. doi: 10.1016/j.cca.2014.12.005. Epub 2014 Dec 23. Clin Chim Acta. 2015. PMID: 25540887
48 results