EZH2 deletion in early mesenchyme compromises postnatal bone microarchitecture and structural integrity and accelerates remodeling.
Hemming S, Cakouros D, Codrington J, Vandyke K, Arthur A, Zannettino A, Gronthos S.
Hemming S, et al. Among authors: zannettino a.
FASEB J. 2017 Mar;31(3):1011-1027. doi: 10.1096/fj.201600748R. Epub 2016 Dec 1.
FASEB J. 2017.
PMID: 27934660
In this study, we examined the functional importance of EZH2 during skeletal development and homeostasis using the conditional deletion of Ezh2 (Ezh2(fl/fl) ) in early mesenchyme with the use of a Prrx-1-cre driver mouse (Ezh2(+/+)). Heterozygous (Ezh2(+/-)) newborn and 4- …
In this study, we examined the functional importance of EZH2 during skeletal development and homeostasis using the conditional deletion of E …