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Calcium-dependent disorder-to-order transitions are central to the secretion and folding of the CyaA toxin of Bordetella pertussis, the causative agent of whooping cough.
O'Brien DP, Perez ACS, Karst J, Cannella SE, Enguéné VYN, Hessel A, Raoux-Barbot D, Voegele A, Subrini O, Davi M, Guijarro JI, Raynal B, Baron B, England P, Hernandez B, Ghomi M, Hourdel V, Malosse C, Chamot-Rooke J, Vachette P, Durand D, Brier S, Ladant D, Chenal A. O'Brien DP, et al. Among authors: ladant d. Toxicon. 2018 Jul;149:37-44. doi: 10.1016/j.toxicon.2018.01.007. Epub 2018 Jan 12. Toxicon. 2018. PMID: 29337218 Review.
Post-translational acylation controls the folding and functions of the CyaA RTX toxin.
O'Brien DP, Cannella SE, Voegele A, Raoux-Barbot D, Davi M, Douché T, Matondo M, Brier S, Ladant D, Chenal A. O'Brien DP, et al. Among authors: ladant d. FASEB J. 2019 Sep;33(9):10065-10076. doi: 10.1096/fj.201802442RR. Epub 2019 Jun 21. FASEB J. 2019. PMID: 31226003
Coupling calcium-binding and acylation-driven folding is likely pertinent for other repeat-in-toxin cytolysins produced by many Gram-negative bacterial pathogens.-O'Brien, D. P., Cannella, S. E., Voegele, A., Raoux-Barbot, D., Davi, M., Douche, T., Matondo, M., Brie …
Coupling calcium-binding and acylation-driven folding is likely pertinent for other repeat-in-toxin cytolysins produced by many Gram-negativ …
A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.
Voegele A, Sadi M, O'Brien DP, Gehan P, Raoux-Barbot D, Davi M, Hoos S, Brûlé S, Raynal B, Weber P, Mechaly A, Haouz A, Rodriguez N, Vachette P, Durand D, Brier S, Ladant D, Chenal A. Voegele A, et al. Among authors: ladant d. Adv Sci (Weinh). 2021 Mar 8;8(9):2003630. doi: 10.1002/advs.202003630. eCollection 2021 May. Adv Sci (Weinh). 2021. PMID: 33977052 Free PMC article.
143 results