Huang PH - Search Results

1

Suppression of Tumor Growth and Muscle Wasting in a Transgenic Mouse Model of Pancreatic Cancer by the Novel Histone Deacetylase Inhibitor AR-42.

Henderson SE, Ding LY, Mo X, Bekaii-Saab T, Kulp SK, Chen CS, Huang PH. Henderson SE, et al. Among authors: huang ph. Neoplasia. 2016 Dec;18(12):765-774. doi: 10.1016/j.neo.2016.10.003. Epub 2016 Nov 25. Neoplasia. 2016. PMID: 27889645 Free PMC article.

2

Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation.

Chen CS, Wang YC, Yang HC, Huang PH, Kulp SK, Yang CC, Lu YS, Matsuyama S, Chen CY, Chen CS. Chen CS, et al. Among authors: huang ph. Cancer Res. 2007 Jun 1;67(11):5318-27. doi: 10.1158/0008-5472.CAN-06-3996. Cancer Res. 2007. Retraction in: Cancer Res. 2018 Jul 15;78(14):4097. doi: 10.1158/0008-5472.CAN-18-1291 PMID: 17545612 Retracted.

3

alpha-Tocopheryl succinate and derivatives mediate the transcriptional repression of androgen receptor in prostate cancer cells by targeting the PP2A-JNK-Sp1-signaling axis.

Huang PH, Wang D, Chuang HC, Wei S, Kulp SK, Chen CS. Huang PH, et al. Carcinogenesis. 2009 Jul;30(7):1125-31. doi: 10.1093/carcin/bgp112. Epub 2009 May 6. Carcinogenesis. 2009. PMID: 19420015 Free PMC article.

4

alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion.

Wang D, Chuang HC, Weng SC, Huang PH, Hsieh HY, Kulp SK, Chen CS. Wang D, et al. Among authors: huang ph. J Med Chem. 2009 Sep 24;52(18):5642-8. doi: 10.1021/jm9002457. J Med Chem. 2009. PMID: 19708661 Free PMC article.

5

Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases.

Huang PH, Chen CH, Chou CC, Sargeant AM, Kulp SK, Teng CM, Byrd JC, Chen CS. Huang PH, et al. Mol Pharmacol. 2011 Jan;79(1):197-206. doi: 10.1124/mol.110.067702. Epub 2010 Oct 19. Mol Pharmacol. 2011. PMID: 20959362 Free PMC article.

6

Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis.

Wang B, Huang PH, Chen CS, Forsyth CJ. Wang B, et al. Among authors: huang ph. J Org Chem. 2011 Feb 18;76(4):1140-50. doi: 10.1021/jo102478x. Epub 2011 Jan 18. J Org Chem. 2011. PMID: 21244075 Free PMC article.

7

Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression.

Chen CH, Huang PH, Chu PC, Chen MC, Chou CC, Wang D, Kulp SK, Teng CM, Wang Q, Chen CS. Chen CH, et al. Among authors: huang ph. J Biol Chem. 2011 Mar 25;286(12):9968-76. doi: 10.1074/jbc.M110.203240. Epub 2011 Jan 31. J Biol Chem. 2011. PMID: 21282102 Free PMC article.

8

Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo.

Lai MJ, Huang HL, Pan SL, Liu YM, Peng CY, Lee HY, Yeh TK, Huang PH, Teng CM, Chen CS, Chuang HY, Liou JP. Lai MJ, et al. Among authors: huang hl, huang ph. J Med Chem. 2012 Apr 26;55(8):3777-91. doi: 10.1021/jm300197a. Epub 2012 Apr 5. J Med Chem. 2012. PMID: 22439863 Free PMC article.

9

Effects of Histone Deacetylase Inhibitors on Modulating H3K4 Methylation Marks - A Novel Cross-Talk Mechanism between Histone-Modifying Enzymes.

Huang PH, Plass C, Chen CS. Huang PH, et al. Mol Cell Pharmacol. 2011;3(2):39-43. Mol Cell Pharmacol. 2011. PMID: 22468166 Free PMC article.

10

Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1.

Huang PH, Chuang HC, Chou CC, Wang H, Lee SL, Yang HC, Chiu HC, Kapuriya N, Wang D, Kulp SK, Chen CS. Huang PH, et al. Sci Signal. 2013 Mar 19;6(267):ra19. doi: 10.1126/scisignal.2003816. Sci Signal. 2013. PMID: 23512990 Free PMC article.

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