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A systems study reveals concurrent activation of AMPK and mTOR by amino acids.
Dalle Pezze P, Ruf S, Sonntag AG, Langelaar-Makkinje M, Hall P, Heberle AM, Razquin Navas P, van Eunen K, Tölle RC, Schwarz JJ, Wiese H, Warscheid B, Deitersen J, Stork B, Fäßler E, Schäuble S, Hahn U, Horvatovich P, Shanley DP, Thedieck K. Dalle Pezze P, et al. Among authors: shanley dp. Nat Commun. 2016 Nov 21;7:13254. doi: 10.1038/ncomms13254. Nat Commun. 2016. PMID: 27869123 Free PMC article.
Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed.
Tomalin LE, Day AM, Underwood ZE, Smith GR, Dalle Pezze P, Rallis C, Patel W, Dickinson BC, Bähler J, Brewer TF, Chang CJ, Shanley DP, Veal EA. Tomalin LE, et al. Among authors: shanley dp. Free Radic Biol Med. 2016 Jun;95:333-48. doi: 10.1016/j.freeradbiomed.2016.02.035. Epub 2016 Mar 2. Free Radic Biol Med. 2016. PMID: 26944189 Free PMC article.
Towards an e-biology of ageing: integrating theory and data.
Kirkwood TB, Boys RJ, Gillespie CS, Proctor CJ, Shanley DP, Wilkinson DJ. Kirkwood TB, et al. Among authors: shanley dp. Nat Rev Mol Cell Biol. 2003 Mar;4(3):243-9. doi: 10.1038/nrm1051. Nat Rev Mol Cell Biol. 2003. PMID: 12612643
51 results