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Regression of Atherosclerosis in ApoE-/- Mice Via Modulation of Monocyte Recruitment and Phenotype, Induced by Weekly Dosing of a Novel "Cytotopic" Anti-Thrombin Without Prolonged Anticoagulation.
Chen D, Li K, Festenstein S, Karegli J, Wilkinson H, Leonard H, Wei LL, Ma N, Xia M, Tam H, Wang JA, Xu Q, McVey JH, Smith RAG, Dorling A. Chen D, et al. J Am Heart Assoc. 2020 Jul 7;9(13):e014811. doi: 10.1161/JAHA.119.014811. Epub 2020 Jul 2. J Am Heart Assoc. 2020. PMID: 32611229 Free PMC article.
Manipulation of tissue factor-mediated basal PAR-2 signalling on macrophages determines sensitivity for IFNγ responsiveness and significantly modifies the phenotype of murine DTH.
Wilkinson H, Leonard H, Robson MG, Smith R, Tam E, McVey JH, Kirckhofer D, Chen D, Dorling A. Wilkinson H, et al. Among authors: smith r. Front Immunol. 2022 Sep 12;13:999871. doi: 10.3389/fimmu.2022.999871. eCollection 2022. Front Immunol. 2022. PMID: 36172348 Free PMC article.
Inhibition of thrombin on endothelium enhances recruitment of regulatory T cells during IRI and when combined with adoptive Treg transfer, significantly protects against acute tissue injury and prolongs allograft survival.
Peng Q, Nowocin A, Ratnasothy K, Smith RA, Smyth LA, Lechler RI, Dorling A, Lombardi G. Peng Q, et al. Front Immunol. 2023 Jan 30;13:980462. doi: 10.3389/fimmu.2022.980462. eCollection 2022. Front Immunol. 2023. PMID: 36793549 Free PMC article.
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