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Patient-derived orthotopic xenograft (PDOX) mouse model of adult rhabdomyosarcoma invades and recurs after resection in contrast to the subcutaneous ectopic model.
Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh A, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM. Igarashi K, et al. Among authors: kimura h. Cell Cycle. 2017 Jan 2;16(1):91-94. doi: 10.1080/15384101.2016.1252885. Epub 2016 Nov 10. Cell Cycle. 2017. PMID: 27830986 Free PMC article.
High Efficacy of Pazopanib on an Undifferentiated Spindle-Cell Sarcoma Resistant to First-Line Therapy Is Identified With a Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model.
Igarashi K, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Singh AS, Nelson SD, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. Igarashi K, et al. Among authors: kimura h. J Cell Biochem. 2017 Sep;118(9):2739-2743. doi: 10.1002/jcb.25923. Epub 2017 Apr 25. J Cell Biochem. 2017. PMID: 28176365
Intra-arterial administration of tumor-targeting Salmonella typhimurium A1-R regresses a cisplatin-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model.
Igarashi K, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Nelson SD, Dry SM, Li Y, Yanagawa J, Russell TA, Singh AS, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. Igarashi K, et al. Among authors: kimura h. Cell Cycle. 2017 Jun 18;16(12):1164-1170. doi: 10.1080/15384101.2017.1317417. Epub 2017 May 11. Cell Cycle. 2017. PMID: 28494180 Free PMC article.
A novel anionic-phosphate-platinum complex effectively targets an undifferentiated pleomorphic sarcoma better than cisplatinum and doxorubicin in a patient-derived orthotopic xenograft (PDOX).
Igarashi K, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Yamamoto N, Hayashi K, Kimura H, Nelson SD, Dry SM, Li Y, Singh AS, Miwa S, Odani A, Eilber FC, Tsuchiya H, Hoffman RM. Igarashi K, et al. Among authors: kimura h. Oncotarget. 2017 Jun 28;8(38):63353-63359. doi: 10.18632/oncotarget.18806. eCollection 2017 Sep 8. Oncotarget. 2017. PMID: 28968995 Free PMC article.
Temozolomide combined with irinotecan caused regression in an adult pleomorphic rhabdomyosarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model.
Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh AS, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM. Igarashi K, et al. Among authors: kimura h. Oncotarget. 2017 Mar 24;8(44):75874-75880. doi: 10.18632/oncotarget.16548. eCollection 2017 Sep 29. Oncotarget. 2017. PMID: 29100276 Free PMC article.
Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase.
Igarashi K, Li S, Han Q, Tan Y, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM. Igarashi K, et al. Among authors: kimura h. J Cell Biochem. 2018 Apr;119(4):3537-3544. doi: 10.1002/jcb.26527. Epub 2018 Jan 2. J Cell Biochem. 2018. PMID: 29143983 Free article.
Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma.
Igarashi K, Kawaguchi K, Li S, Han Q, Tan Y, Murakami T, Kiyuna T, Miyake K, Miyake M, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Singh SR, Eilber FC, Hoffman RM. Igarashi K, et al. Among authors: kimura h. Cancer Lett. 2018 Mar 28;417:168-173. doi: 10.1016/j.canlet.2017.12.028. Epub 2018 Jan 3. Cancer Lett. 2018. PMID: 29306021
5,926 results