Soares AS - Search Results

1

An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis.

Kayode O, Wang R, Pendlebury DF, Cohen I, Henin RD, Hockla A, Soares AS, Papo N, Caulfield TR, Radisky ES. Kayode O, et al. Among authors: soares as. J Biol Chem. 2016 Dec 16;291(51):26304-26319. doi: 10.1074/jbc.M116.758417. Epub 2016 Nov 3. J Biol Chem. 2016. PMID: 27810896 Free PMC article.

2

Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsin.

Salameh MA, Soares AS, Hockla A, Radisky ES. Salameh MA, et al. Among authors: soares as. J Biol Chem. 2008 Feb 15;283(7):4115-23. doi: 10.1074/jbc.M708268200. Epub 2007 Dec 12. J Biol Chem. 2008. PMID: 18077447 Free article.

3

Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin.

Salameh MA, Soares AS, Navaneetham D, Sinha D, Walsh PN, Radisky ES. Salameh MA, et al. Among authors: soares as. J Biol Chem. 2010 Nov 19;285(47):36884-96. doi: 10.1074/jbc.M110.171348. Epub 2010 Sep 22. J Biol Chem. 2010. PMID: 20861008 Free PMC article.

4

Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure.

Batra J, Robinson J, Soares AS, Fields AP, Radisky DC, Radisky ES. Batra J, et al. Among authors: soares as. J Biol Chem. 2012 May 4;287(19):15935-46. doi: 10.1074/jbc.M112.341156. Epub 2012 Mar 16. J Biol Chem. 2012. PMID: 22427646 Free PMC article.

5

Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors.

Salameh MA, Soares AS, Alloy A, Radisky ES. Salameh MA, et al. Among authors: soares as. Protein Sci. 2012 Aug;21(8):1103-12. doi: 10.1002/pro.2097. Epub 2012 Jun 25. Protein Sci. 2012. PMID: 22610453 Free PMC article.

6

Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation.

Batra J, Szabó A, Caulfield TR, Soares AS, Sahin-Tóth M, Radisky ES. Batra J, et al. Among authors: soares as. J Biol Chem. 2013 Apr 5;288(14):9848-9859. doi: 10.1074/jbc.M113.457382. Epub 2013 Feb 19. J Biol Chem. 2013. PMID: 23430245 Free PMC article.

7

Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin.

Pendlebury D, Wang R, Henin RD, Hockla A, Soares AS, Madden BJ, Kazanov MD, Radisky ES. Pendlebury D, et al. Among authors: soares as. J Biol Chem. 2014 Nov 21;289(47):32783-97. doi: 10.1074/jbc.M114.609560. Epub 2014 Oct 9. J Biol Chem. 2014. PMID: 25301953 Free PMC article.

8

Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates.

Alloy AP, Kayode O, Wang R, Hockla A, Soares AS, Radisky ES. Alloy AP, et al. Among authors: soares as. J Biol Chem. 2015 Aug 28;290(35):21523-35. doi: 10.1074/jbc.M115.662429. Epub 2015 Jul 14. J Biol Chem. 2015. PMID: 26175157 Free PMC article.

9

The P(2)' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity.

Salameh MA, Soares AS, Hockla A, Radisky DC, Radisky ES. Salameh MA, et al. Among authors: soares as. Biochem J. 2011 Nov 15;440(1):95-105. doi: 10.1042/BJ20110788. Biochem J. 2011. PMID: 21806544 Free PMC article.

10

Small molecule inhibitors of mesotrypsin from a structure-based docking screen.

Kayode O, Huang Z, Soares AS, Caulfield TR, Dong Z, Bode AM, Radisky ES. Kayode O, et al. Among authors: soares as. PLoS One. 2017 May 2;12(5):e0176694. doi: 10.1371/journal.pone.0176694. eCollection 2017. PLoS One. 2017. PMID: 28463992 Free PMC article.

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