Morikami K - Search Results

1

Development of a Method for Converting a TAK1 Type I Inhibitor into a Type II or c-Helix-Out Inhibitor by Structure-Based Drug Design (SBDD).

Muraoka T, Ide M, Irie M, Morikami K, Miura T, Nishihara M, Kashiwagi H. Muraoka T, et al. Among authors: morikami k. Chem Pharm Bull (Tokyo). 2016;64(11):1622-1629. doi: 10.1248/cpb.c16-00606. Chem Pharm Bull (Tokyo). 2016. PMID: 27803473 Free article.

2

Discovery of a potent and highly selective transforming growth factor β receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD).

Muraoka T, Ide M, Morikami K, Irie M, Nakamura M, Miura T, Kamikawa T, Nishihara M, Kashiwagi H. Muraoka T, et al. Among authors: morikami k. Bioorg Med Chem. 2016 Sep 15;24(18):4206-4217. doi: 10.1016/j.bmc.2016.07.006. Epub 2016 Jul 6. Bioorg Med Chem. 2016. PMID: 27448772

3

Identification of a selective inhibitor of transforming growth factor β-activated kinase 1 by biosensor-based screening of focused libraries.

Miura T, Matsuo A, Muraoka T, Ide M, Morikami K, Kamikawa T, Nishihara M, Kashiwagi H. Miura T, et al. Among authors: morikami k. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1031-1036. doi: 10.1016/j.bmcl.2016.12.064. Epub 2016 Dec 29. Bioorg Med Chem Lett. 2017. PMID: 28109791

4

Systematic SAR study of the side chain of nonsecosteroidal vitamin D₃ analogs.

Kashiwagi H, Ono Y, Ohta M, Morikami K, Takahashi T. Kashiwagi H, et al. Among authors: morikami k. Bioorg Med Chem. 2012 Jul 15;20(14):4495-506. doi: 10.1016/j.bmc.2012.05.023. Epub 2012 May 18. Bioorg Med Chem. 2012. PMID: 22677528

5

Effects of fluorines on nonsecosteroidal vitamin D receptor agonists.

Kashiwagi H, Ohta M, Ono Y, Morikami K, Itoh S, Sato H, Takahashi T. Kashiwagi H, et al. Among authors: morikami k. Bioorg Med Chem. 2013 Feb 1;21(3):712-21. doi: 10.1016/j.bmc.2012.11.029. Epub 2012 Dec 2. Bioorg Med Chem. 2013. PMID: 23266184

6

Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.

Lito P, Saborowski A, Yue J, Solomon M, Joseph E, Gadal S, Saborowski M, Kastenhuber E, Fellmann C, Ohara K, Morikami K, Miura T, Lukacs C, Ishii N, Lowe S, Rosen N. Lito P, et al. Among authors: morikami k. Cancer Cell. 2014 May 12;25(5):697-710. doi: 10.1016/j.ccr.2014.03.011. Epub 2014 Apr 17. Cancer Cell. 2014. PMID: 24746704 Free PMC article.

7

Monte Carlo simulations on atropisomerism of thienotriazolodiazepines applicable to slow transition phenomena using potential energy surfaces by ab initio molecular orbital calculations.

Morikami K, Itezono Y, Nishimoto M, Ohta M. Morikami K, et al. Chem Pharm Bull (Tokyo). 2014;62(3):229-37. doi: 10.1248/cpb.c13-00637. Chem Pharm Bull (Tokyo). 2014. PMID: 24583777 Free article.

8

Lead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation.

Kawada H, Ebiike H, Tsukazaki M, Nakamura M, Morikami K, Yoshinari K, Yoshida M, Ogawa K, Shimma N, Tsukuda T, Ohwada J. Kawada H, et al. Among authors: morikami k. Bioorg Med Chem Lett. 2013 Feb 1;23(3):673-8. doi: 10.1016/j.bmcl.2012.11.112. Epub 2012 Dec 3. Bioorg Med Chem Lett. 2013. PMID: 23265889

9

Discovery of [5-Amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-(1H-indol-2-yl)methanone (CH5183284/Debio 1347), An Orally Available and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.

Ebiike H, Taka N, Matsushita M, Ohmori M, Takami K, Hyohdoh I, Kohchi M, Hayase T, Nishii H, Morikami K, Nakanishi Y, Akiyama N, Shindoh H, Ishii N, Isobe T, Matsuoka H. Ebiike H, et al. Among authors: morikami k. J Med Chem. 2016 Dec 8;59(23):10586-10600. doi: 10.1021/acs.jmedchem.6b01156. Epub 2016 Nov 29. J Med Chem. 2016. PMID: 27933954

10

Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors.

Nishii H, Chiba T, Morikami K, Fukami TA, Sakamoto H, Ko K, Koyano H. Nishii H, et al. Among authors: morikami k. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1405-9. doi: 10.1016/j.bmcl.2009.12.109. Epub 2010 Jan 4. Bioorg Med Chem Lett. 2010. PMID: 20093027

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