Tan L - Search Results

1

Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction.

Hyde AM, Liu Z, Kosjek B, Tan L, Klapars A, Ashley ER, Zhong YL, Alvizo O, Agard NJ, Liu G, Gu X, Yasuda N, Limanto J, Huffman MA, Tschaen DM. Hyde AM, et al. Among authors: tan l. Org Lett. 2016 Nov 18;18(22):5888-5891. doi: 10.1021/acs.orglett.6b02910. Epub 2016 Nov 1. Org Lett. 2016. PMID: 27802043

2

Scalable Asymmetric Synthesis of MK-8998, a T-Type Calcium Channel Antagonist.

Zhong YL, Moore JC, Shevlin M, Shultz CS, Kosjek B, Chen Y, Janey JM, Tan L. Zhong YL, et al. Among authors: tan l. J Org Chem. 2022 Feb 18;87(4):2120-2128. doi: 10.1021/acs.joc.1c01795. Epub 2021 Sep 28. J Org Chem. 2022. PMID: 34582192

3

Dynamic kinetic resolution: asymmetric transfer hydrogenation of alpha-alkyl-substituted beta-ketoamides.

Limanto J, Krska SW, Dorner BT, Vazquez E, Yoshikawa N, Tan L. Limanto J, et al. Among authors: tan l. Org Lett. 2010 Feb 5;12(3):512-5. doi: 10.1021/ol902715d. Org Lett. 2010. PMID: 20028132

4

Synthesis of bis-macrocyclic HCV protease inhibitor MK-6325 via intramolecular sp²-sp³ Suzuki-Miyaura coupling and ring closing metathesis.

Li H, Scott JP, Chen CY, Journet M, Belyk K, Balsells J, Kosjek B, Baxter CA, Stewart GW, Wise C, Alam M, Song ZJ, Tan L. Li H, et al. Among authors: tan l. Org Lett. 2015 Mar 20;17(6):1533-6. doi: 10.1021/acs.orglett.5b00418. Epub 2015 Mar 10. Org Lett. 2015. PMID: 25754231

5

Promotion of a Ti-Mediated Mannich Reaction by a Proton Source.

Limanto J, Yoshikawa N, Reamer RA, Tan L, Brunskill A, Reibarkh M. Limanto J, et al. Among authors: tan l. J Org Chem. 2016 Jan 15;81(2):723-8. doi: 10.1021/acs.joc.5b02452. Epub 2015 Dec 21. J Org Chem. 2016. PMID: 26656787

6

Highly Diastereoselective Synthesis of a HCV NS5B Nucleoside Polymerase Inhibitor.

Zhong YL, Cleator E, Liu Z, Yin J, Morris WJ, Alam M, Bishop B, Dumas AM, Edwards J, Goodyear A, Mullens P, Song ZJ, Shevlin M, Thaisrivongs DA, Li H, Sherer EC, Cohen RD, Yin J, Tan L, Yasuda N, Limanto J, Davies A, Campos KR. Zhong YL, et al. Among authors: tan l. J Org Chem. 2019 Apr 19;84(8):4780-4795. doi: 10.1021/acs.joc.8b02500. Epub 2018 Dec 10. J Org Chem. 2019. PMID: 30475616

7

Practical asymmetric synthesis of a selective endothelin A receptor (ETA) antagonist.

Song ZJ, Zhao M, Frey L, Li J, Tan L, Chen CY, Tschaen DM, Tillyer R, Grabowski EJ, Volante R, Reider PJ, Kato Y, Okada S, Nemoto T, Sato H, Akao A, Mase T. Song ZJ, et al. Among authors: tan l. Org Lett. 2001 Oct 18;3(21):3357-60. doi: 10.1021/ol016601s. Org Lett. 2001. PMID: 11594833

8

Stereoselective syntheses of highly functionalized bicyclo[3.1.0]hexanes: a general methodology for the synthesis of potent and selective mGluR2/3 agonists.

Tan L, Yasuda N, Yoshikawa N, Hartner FW, Eng KK, Leonard WR, Tsay FR, Volante RP, Tillyer RD. Tan L, et al. J Org Chem. 2005 Sep 30;70(20):8027-34. doi: 10.1021/jo0511187. J Org Chem. 2005. PMID: 16277324

9

Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods.

Klapars A, Chung JYL, Limanto J, Calabria R, Campeau LC, Campos KR, Chen W, Dalby SM, Davis TA, DiRocco DA, Hyde AM, Kassim AM, Larsen MU, Liu G, Maligres PE, Moment A, Peng F, Ruck RT, Shevlin M, Simmons BL, Song ZJ, Tan L, Wright TJ, Zultanski SL. Klapars A, et al. Among authors: tan l. Chem Sci. 2021 May 19;12(26):9031-9036. doi: 10.1039/d1sc01978c. eCollection 2021 Jul 7. Chem Sci. 2021. PMID: 34276931 Free PMC article.

10

An efficient synthesis of an alphavbeta3 antagonist.

Yasuda N, Hsiao Y, Jensen MS, Rivera NR, Yang C, Wells KM, Yau J, Palucki M, Tan L, Dormer PG, Volante RP, Hughes DL, Reider PJ. Yasuda N, et al. Among authors: tan l. J Org Chem. 2004 Mar 19;69(6):1959-66. doi: 10.1021/jo030297u. J Org Chem. 2004. PMID: 15058940

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