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S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis.
Geven EJ, van den Bosch MH, Di Ceglie I, Ascone G, Abdollahi-Roodsaz S, Sloetjes AW, Hermann S, Schäfers M, van de Loo FA, van der Kraan PM, Koenders MI, Foell D, Roth J, Vogl T, van Lent PL. Geven EJ, et al. Arthritis Res Ther. 2016 Oct 24;18(1):247. doi: 10.1186/s13075-016-1121-z. Arthritis Res Ther. 2016. PMID: 27776554 Free PMC article.
The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis.
Blom AB, van den Bosch MH, Blaney Davidson EN, Roth J, Vogl T, van de Loo FA, Koenders M, van der Kraan PM, Geven EJ, van Lent PL. Blom AB, et al. Among authors: geven ej. Arthritis Res Ther. 2020 Aug 27;22(1):199. doi: 10.1186/s13075-020-02295-9. Arthritis Res Ther. 2020. PMID: 32854769 Free PMC article.
S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis.
Cremers NAJ, van den Bosch MHJ, van Dalen S, Di Ceglie I, Ascone G, van de Loo F, Koenders M, van der Kraan P, Sloetjes A, Vogl T, Roth J, Geven EJW, Blom AB, van Lent PLEM. Cremers NAJ, et al. Among authors: geven ejw. Arthritis Res Ther. 2017 Sep 29;19(1):217. doi: 10.1186/s13075-017-1426-6. Arthritis Res Ther. 2017. PMID: 28969686 Free PMC article.
Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.
Schelbergen RF, Geven EJ, van den Bosch MH, Eriksson H, Leanderson T, Vogl T, Roth J, van de Loo FA, Koenders MI, van der Kraan PM, van den Berg WB, Blom AB, van Lent PL. Schelbergen RF, et al. Among authors: geven ej. Ann Rheum Dis. 2015 Dec;74(12):2254-8. doi: 10.1136/annrheumdis-2014-206517. Epub 2015 May 12. Ann Rheum Dis. 2015. PMID: 25969431
IL-1β-Mediated Activation of Adipose-Derived Mesenchymal Stromal Cells Results in PMN Reallocation and Enhanced Phagocytosis: A Possible Mechanism for the Reduction of Osteoarthritis Pathology.
van Dalen SCM, Blom AB, Walgreen B, Slöetjes AW, Helsen MMA, Geven EJW, Ter Huurne M, Vogl T, Roth J, van de Loo FAJ, Koenders MI, Casteilla L, van der Kraan PM, van den Bosch MHJ, van Lent PLEM. van Dalen SCM, et al. Among authors: geven ejw. Front Immunol. 2019 May 27;10:1075. doi: 10.3389/fimmu.2019.01075. eCollection 2019. Front Immunol. 2019. PMID: 31191517 Free PMC article.
Synovial macrophages promote TGF-β signaling and protect against influx of S100A8/S100A9-producing cells after intra-articular injections of oxidized low-density lipoproteins.
de Munter W, Geven EJ, Blom AB, Walgreen B, Helsen MM, Joosten LA, Roth J, Vogl T, van de Loo FA, Koenders MI, van den Berg WB, van der Kraan PM, van Lent PL. de Munter W, et al. Among authors: geven ej. Osteoarthritis Cartilage. 2017 Jan;25(1):118-127. doi: 10.1016/j.joca.2016.07.020. Epub 2016 Aug 8. Osteoarthritis Cartilage. 2017. PMID: 27514996 Free article.
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