Das TK - Search Results

1

Technical Decision Making With Higher Order Structure Data: Perspectives on Higher Order Structure Characterization From the Biopharmaceutical Industry.

Weiss WF 4th, Gabrielson JP, Al-Azzam W, Chen G, Davis DL, Das TK, Hayes DB, Houde D, Singh SK. Weiss WF 4th, et al. Among authors: das tk. J Pharm Sci. 2016 Dec;105(12):3465-3470. doi: 10.1016/j.xphs.2016.09.003. Epub 2016 Oct 13. J Pharm Sci. 2016. PMID: 27743675 Review.

2

Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies.

Wang X, Das TK, Singh SK, Kumar S. Wang X, et al. Among authors: das tk. MAbs. 2009 May-Jun;1(3):254-67. doi: 10.4161/mabs.1.3.8035. Epub 2009 May 29. MAbs. 2009. PMID: 20065649 Free PMC article.

3

Aggregation and pH-temperature phase behavior for aggregates of an IgG2 antibody.

Sahin E, Weiss WF 4th, Kroetsch AM, King KR, Kessler RK, Das TK, Roberts CJ. Sahin E, et al. Among authors: das tk. J Pharm Sci. 2012 May;101(5):1678-87. doi: 10.1002/jps.23056. Epub 2012 Jan 13. J Pharm Sci. 2012. PMID: 22246657

4

Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification-Structure-Function Correlations by Hydrogen-Deuterium Exchange Mass Spectrometry.

Yan Y, Wei H, Fu Y, Jusuf S, Zeng M, Ludwig R, Krystek SR Jr, Chen G, Tao L, Das TK. Yan Y, et al. Among authors: das tk. Anal Chem. 2016 Feb 16;88(4):2041-50. doi: 10.1021/acs.analchem.5b02800. Epub 2016 Jan 29. Anal Chem. 2016. PMID: 26824491

5

Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry.

Huang RY, Iacob RE, Krystek SR, Jin M, Wei H, Tao L, Das TK, Tymiak AA, Engen JR, Chen G. Huang RY, et al. Among authors: das tk. J Am Soc Mass Spectrom. 2017 May;28(5):795-802. doi: 10.1007/s13361-016-1452-7. Epub 2016 Aug 15. J Am Soc Mass Spectrom. 2017. PMID: 27527097

6

Mapping the Binding Interface in a Noncovalent Size Variant of a Monoclonal Antibody Using Native Mass Spectrometry, Hydrogen-Deuterium Exchange Mass Spectrometry, and Computational Analysis.

Yan Y, Wei H, Jusuf S, Krystek SR Jr, Chen J, Chen G, Ludwig RT, Tao L, Das TK. Yan Y, et al. Among authors: das tk. J Pharm Sci. 2017 Nov;106(11):3222-3229. doi: 10.1016/j.xphs.2017.06.009. Epub 2017 Jun 17. J Pharm Sci. 2017. PMID: 28634122

7

Submicron Protein Particle Characterization using Resistive Pulse Sensing and Conventional Light Scattering Based Approaches.

Barnett GV, Perhacs JM, Das TK, Kar SR. Barnett GV, et al. Among authors: das tk. Pharm Res. 2018 Feb 8;35(3):58. doi: 10.1007/s11095-017-2306-0. Pharm Res. 2018. PMID: 29423663

8

Enhanced Precision of Circular Dichroism Spectral Measurements Permits Detection of Subtle Higher Order Structural Changes in Therapeutic Proteins.

Barnett GV, Balakrishnan G, Chennamsetty N, Meengs B, Meyer J, Bongers J, Ludwig R, Tao L, Das TK, Leone A, Kar SR. Barnett GV, et al. Among authors: das tk. J Pharm Sci. 2018 Oct;107(10):2559-2569. doi: 10.1016/j.xphs.2018.06.007. Epub 2018 Jun 18. J Pharm Sci. 2018. PMID: 29913140

9

Probing the Tryptophan Environment in Therapeutic Proteins: Implications for Higher Order Structure on Tryptophan Oxidation.

Barnett GV, Balakrishnan G, Chennamsetty N, Hoffman L, Bongers J, Tao L, Huang Y, Slaney T, Das TK, Leone A, Kar SR. Barnett GV, et al. Among authors: das tk. J Pharm Sci. 2019 Jun;108(6):1944-1952. doi: 10.1016/j.xphs.2018.12.027. Epub 2019 Jan 11. J Pharm Sci. 2019. PMID: 30639740

10

Structure-Function Assessment and High-Throughput Quantification of Site-Specific Aspartate Isomerization in Monoclonal Antibody Using a Novel Analytical Tool Kit.

Zhou K, Cao X, Bautista J, Chen Z, Hershey N, Ludwig R, Tao L, Zeng M, Das TK. Zhou K, et al. Among authors: das tk. J Pharm Sci. 2020 Jan;109(1):422-428. doi: 10.1016/j.xphs.2019.08.018. Epub 2019 Aug 27. J Pharm Sci. 2020. PMID: 31469998

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