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Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells.
Wong WF, Kohu K, Nakamura A, Ebina M, Kikuchi T, Tazawa R, Tanaka K, Kon S, Funaki T, Sugahara-Tobinai A, Looi CY, Endo S, Funayama R, Kurokawa M, Habu S, Ishii N, Fukumoto M, Nakata K, Takai T, Satake M. Wong WF, et al. Among authors: sugahara tobinai a. J Immunol. 2012 Jun 1;188(11):5408-20. doi: 10.4049/jimmunol.1102991. Epub 2012 May 2. J Immunol. 2012. PMID: 22551552
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