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TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction.
Rogers NM, Sharifi-Sanjani M, Yao M, Ghimire K, Bienes-Martinez R, Mutchler SM, Knupp HE, Baust J, Novelli EM, Ross M, St Croix C, Kutten JC, Czajka CA, Sembrat JC, Rojas M, Labrousse-Arias D, Bachman TN, Vanderpool RR, Zuckerbraun BS, Champion HC, Mora AL, Straub AC, Bilonick RA, Calzada MJ, Isenberg JS. Rogers NM, et al. Among authors: novelli em. Cardiovasc Res. 2017 Jan;113(1):15-29. doi: 10.1093/cvr/cvw218. Epub 2016 Oct 13. Cardiovasc Res. 2017. PMID: 27742621 Free PMC article.
Thrombospondin-1 inhibits ADAMTS13 activity in sickle cell disease.
Novelli EM, Kato GJ, Hildesheim ME, Barge S, Meyer MP, Lozier J, Hassett AC, Ragni MV, Isenberg JS, Gladwin MT. Novelli EM, et al. Haematologica. 2013 Nov;98(11):e132-4. doi: 10.3324/haematol.2013.092635. Haematologica. 2013. PMID: 24186313 Free PMC article. No abstract available.
Thrombospondin-1 activation of signal-regulatory protein-α stimulates reactive oxygen species production and promotes renal ischemia reperfusion injury.
Yao M, Rogers NM, Csányi G, Rodriguez AI, Ross MA, St Croix C, Knupp H, Novelli EM, Thomson AW, Pagano PJ, Isenberg JS. Yao M, et al. Among authors: novelli em. J Am Soc Nephrol. 2014 Jun;25(6):1171-86. doi: 10.1681/ASN.2013040433. Epub 2014 Feb 7. J Am Soc Nephrol. 2014. PMID: 24511121 Free PMC article.
Cellular, pharmacological, and biophysical evaluation of explanted lungs from a patient with sickle cell disease and severe pulmonary arterial hypertension.
Rogers NM, Yao M, Sembrat J, George MP, Knupp H, Ross M, Sharifi-Sanjani M, Milosevic J, St Croix C, Rajkumar R, Frid MG, Hunter KS, Mazzaro L, Novelli EM, Stenmark KR, Gladwin MT, Ahmad F, Champion HC, Isenberg JS. Rogers NM, et al. Among authors: novelli em. Pulm Circ. 2013 Dec;3(4):936-51. doi: 10.1086/674754. Pulm Circ. 2013. PMID: 25006410 Free PMC article.
First successful lung transplantation for sickle cell disease with severe pulmonary arterial hypertension and pulmonary veno-occlusive disease.
George MP, Novelli EM, Shigemura N, Simon MA, Feingold B, Krishnamurti L, Morrell MR, Gries CG, Haider S, Johnson BA, Crespo MM, Bhama JK, Bermudez C, Yousem SA, Toyoda Y, Champion HC, Pilewski JM, Gladwin MT. George MP, et al. Among authors: novelli em. Pulm Circ. 2013 Dec;3(4):952-8. doi: 10.1086/674749. Pulm Circ. 2013. PMID: 25006411 Free PMC article.
Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia.
Jacob SA, Novelli EM, Isenberg JS, Garrett ME, Chu Y, Soldano K, Ataga KI, Telen MJ, Ashley-Koch A, Gladwin MT, Zhang Y, Kato GJ. Jacob SA, et al. Among authors: novelli em. Am J Hematol. 2017 Mar;92(3):E31-E34. doi: 10.1002/ajh.24635. Epub 2017 Feb 3. Am J Hematol. 2017. PMID: 28033687 Free PMC article. Clinical Trial. No abstract available.
The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1.
Meijles DN, Sahoo S, Al Ghouleh I, Amaral JH, Bienes-Martinez R, Knupp HE, Attaran S, Sembrat JC, Nouraie SM, Rojas MM, Novelli EM, Gladwin MT, Isenberg JS, Cifuentes-Pagano E, Pagano PJ. Meijles DN, et al. Among authors: novelli em. Sci Signal. 2017 Oct 17;10(501):eaaj1784. doi: 10.1126/scisignal.aaj1784. Sci Signal. 2017. PMID: 29042481 Free PMC article.
Vascular TSP1-CD47 signaling promotes sickle cell-associated arterial vasculopathy and pulmonary hypertension in mice.
Novelli EM, Little-Ihrig L, Knupp HE, Rogers NM, Yao M, Baust JJ, Meijles D, St Croix CM, Ross MA, Pagano PJ, DeVallance ER, Miles G, Potoka KP, Isenberg JS, Gladwin MT. Novelli EM, et al. Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1150-L1164. doi: 10.1152/ajplung.00302.2018. Epub 2019 Mar 20. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 30892078 Free PMC article.
140 results