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Dynamics of mTORC1 activation in response to amino acids.
Manifava M, Smith M, Rotondo S, Walker S, Niewczas I, Zoncu R, Clark J, Ktistakis NT. Manifava M, et al. Among authors: zoncu r. Elife. 2016 Oct 11;5:e19960. doi: 10.7554/eLife.19960. Elife. 2016. PMID: 27725083 Free PMC article.
Amino acids and mTORC1: from lysosomes to disease.
Efeyan A, Zoncu R, Sabatini DM. Efeyan A, et al. Among authors: zoncu r. Trends Mol Med. 2012 Sep;18(9):524-33. doi: 10.1016/j.molmed.2012.05.007. Epub 2012 Jun 28. Trends Mol Med. 2012. PMID: 22749019 Free PMC article. Review.
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM. Wang S, et al. Among authors: zoncu r. Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7. Science. 2015. PMID: 25567906 Free PMC article.
Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.
Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R. Castellano BM, et al. Among authors: zoncu r. Science. 2017 Mar 24;355(6331):1306-1311. doi: 10.1126/science.aag1417. Science. 2017. PMID: 28336668 Free PMC article.
Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.
Su MY, Morris KL, Kim DJ, Fu Y, Lawrence R, Stjepanovic G, Zoncu R, Hurley JH. Su MY, et al. Among authors: zoncu r. Mol Cell. 2017 Dec 7;68(5):835-846.e3. doi: 10.1016/j.molcel.2017.10.016. Epub 2017 Nov 5. Mol Cell. 2017. PMID: 29107538 Free PMC article.
76 results