Shen B - Search Results

1

Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement.

Huang Y, Yang D, Pan G, Tang GL, Shen B. Huang Y, et al. Among authors: shen b. Appl Microbiol Biotechnol. 2016 Dec;100(24):10555-10562. doi: 10.1007/s00253-016-7864-2. Epub 2016 Oct 5. Appl Microbiol Biotechnol. 2016. PMID: 27704182 Free PMC article.

2

Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.

Cheng YQ, Tang GL, Shen B. Cheng YQ, et al. Among authors: shen b. J Bacteriol. 2002 Dec;184(24):7013-24. doi: 10.1128/JB.184.24.7013-7024.2002. J Bacteriol. 2002. PMID: 12446651 Free PMC article.

3

Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis.

Cheng YQ, Tang GL, Shen B. Cheng YQ, et al. Among authors: shen b. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3149-54. doi: 10.1073/pnas.0537286100. Epub 2003 Feb 21. Proc Natl Acad Sci U S A. 2003. PMID: 12598647 Free PMC article.

4

Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase.

Tang GL, Cheng YQ, Shen B. Tang GL, et al. Among authors: shen b. Chem Biol. 2004 Jan;11(1):33-45. doi: 10.1016/j.chembiol.2003.12.014. Chem Biol. 2004. PMID: 15112993 Free article.

5

Hybrid peptide-polyketide natural products: biosynthesis and prospects towards engineering novel molecules.

Du L, Cheng YQ, Ingenhorst G, Tang GL, Huang Y, Shen B. Du L, et al. Among authors: shen b. Genet Eng (N Y). 2003;25:227-67. doi: 10.1007/978-1-4615-0073-5_11. Genet Eng (N Y). 2003. PMID: 15260241 Review. No abstract available.

6

Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus.

Wendt-Pienkowski E, Huang Y, Zhang J, Li B, Jiang H, Kwon H, Hutchinson CR, Shen B. Wendt-Pienkowski E, et al. Among authors: shen b. J Am Chem Soc. 2005 Nov 30;127(47):16442-52. doi: 10.1021/ja054376u. J Am Chem Soc. 2005. PMID: 16305230

7

Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140.

Tang GL, Cheng YQ, Shen B. Tang GL, et al. Among authors: shen b. J Nat Prod. 2006 Mar;69(3):387-93. doi: 10.1021/np050467t. J Nat Prod. 2006. PMID: 16562841 Free PMC article.

8

A dedicated phosphopantetheinyl transferase for the fredericamycin polyketide synthase from Streptomyces griseus.

Huang Y, Wendt-Pienkowski E, Shen B. Huang Y, et al. Among authors: shen b. J Biol Chem. 2006 Oct 6;281(40):29660-8. doi: 10.1074/jbc.M604895200. Epub 2006 Aug 8. J Biol Chem. 2006. PMID: 16895912 Free article.

9

Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load D-alanine.

Tang GL, Cheng YQ, Shen B. Tang GL, et al. Among authors: shen b. J Biol Chem. 2007 Jul 13;282(28):20273-82. doi: 10.1074/jbc.M702814200. Epub 2007 May 14. J Biol Chem. 2007. PMID: 17502372 Free article.

10

Bifunctional acyltransferase/decarboxylase LnmK as the missing link for beta-alkylation in polyketide biosynthesis.

Liu T, Huang Y, Shen B. Liu T, et al. Among authors: shen b. J Am Chem Soc. 2009 May 27;131(20):6900-1. doi: 10.1021/ja9012134. J Am Chem Soc. 2009. PMID: 19405532 Free PMC article.

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