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Molecular imaging in oncology drug development.
Mudd SR, Comley RA, Bergstrom M, Holen KD, Luo Y, Carme S, Fox GB, Martarello L, Beaver JD. Mudd SR, et al. Among authors: comley ra. Drug Discov Today. 2017 Jan;22(1):140-147. doi: 10.1016/j.drudis.2016.09.020. Epub 2016 Sep 28. Drug Discov Today. 2017. PMID: 27693713 Review.
Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist.
Searle G, Beaver JD, Comley RA, Bani M, Tziortzi A, Slifstein M, Mugnaini M, Griffante C, Wilson AA, Merlo-Pich E, Houle S, Gunn R, Rabiner EA, Laruelle M. Searle G, et al. Among authors: comley ra. Biol Psychiatry. 2010 Aug 15;68(4):392-9. doi: 10.1016/j.biopsych.2010.04.038. Biol Psychiatry. 2010. PMID: 20599188 Free article.
Mathematical modelling of [¹¹C]-(+)-PHNO human competition studies.
Searle GE, Beaver JD, Tziortzi A, Comley RA, Bani M, Ghibellini G, Merlo-Pich E, Rabiner EA, Laruelle M, Gunn RN. Searle GE, et al. Among authors: comley ra. Neuroimage. 2013 Mar;68:119-32. doi: 10.1016/j.neuroimage.2012.11.033. Epub 2012 Nov 30. Neuroimage. 2013. PMID: 23207573 Clinical Trial.
Human Kinetic Modeling of the 5HT6 PET Radioligand 11C-GSK215083 and Its Utility for Determining Occupancy at Both 5HT6 and 5HT2A Receptors by SB742457 as a Potential Therapeutic Mechanism of Action in Alzheimer Disease.
Parker CA, Rabiner EA, Gunn RN, Searle G, Martarello L, Comley RA, Davy M, Wilson AA, Houle S, Mizrahi R, Laruelle M, Cunningham VJ. Parker CA, et al. Among authors: comley ra. J Nucl Med. 2015 Dec;56(12):1901-9. doi: 10.2967/jnumed.115.162743. Epub 2015 Sep 17. J Nucl Med. 2015. PMID: 26383152 Free article.
A Comparison of Magnetic Resonance Imaging Methods to Assess Multiple Sclerosis Lesions: Implications for Patient Characterization and Clinical Trial Design.
Haacke EM, Bernitsas E, Subramanian K, Utriainen D, Palutla VK, Yerramsetty K, Kumar P, Sethi SK, Chen Y, Latif Z, Jella P, Gharabaghi S, Wang Y, Zhang X, Comley RA, Beaver J, Luo Y. Haacke EM, et al. Among authors: comley ra. Diagnostics (Basel). 2021 Dec 30;12(1):77. doi: 10.3390/diagnostics12010077. Diagnostics (Basel). 2021. PMID: 35054244 Free PMC article.
[18F]BTK-1: A Novel Positron Emission Tomography Tracer for Imaging Bruton's Tyrosine Kinase.
Skaddan MB, Wooten DW, Wilcox KC, Voorbach MJ, Reuter DR, Jia ZJ, Foster-Duke KD, Hickson JA, Vaidyanathan S, Reed AD, Tovcimak AE, Guo Q, Comley RA, Lee L, Finnema SJ, Mudd SR. Skaddan MB, et al. Among authors: comley ra. Mol Imaging Biol. 2022 Oct;24(5):830-841. doi: 10.1007/s11307-022-01733-1. Epub 2022 Apr 28. Mol Imaging Biol. 2022. PMID: 35482146
Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer's disease.
Venkataraman AV, Mansur A, Rizzo G, Bishop C, Lewis Y, Kocagoncu E, Lingford-Hughes A, Huiban M, Passchier J, Rowe JB, Tsukada H, Brooks DJ, Martarello L, Comley RA, Chen L, Schwarz AJ, Hargreaves R, Gunn RN, Rabiner EA, Matthews PM. Venkataraman AV, et al. Among authors: comley ra. Sci Transl Med. 2022 Aug 17;14(658):eabk1051. doi: 10.1126/scitranslmed.abk1051. Epub 2022 Aug 17. Sci Transl Med. 2022. PMID: 35976998
37 results