Hilgenfeld R - Search Results

1

Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments.

Becker D, Kaczmarska Z, Arkona C, Schulz R, Tauber C, Wolber G, Hilgenfeld R, Coll M, Rademann J. Becker D, et al. Among authors: hilgenfeld r. Nat Commun. 2016 Sep 28;7:12761. doi: 10.1038/ncomms12761. Nat Commun. 2016. PMID: 27677239 Free PMC article.

2

An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors.

Al-Gharabli SI, Shah ST, Weik S, Schmidt MF, Mesters JR, Kuhn D, Klebe G, Hilgenfeld R, Rademann J. Al-Gharabli SI, et al. Among authors: hilgenfeld r. Chembiochem. 2006 Jul;7(7):1048-55. doi: 10.1002/cbic.200500533. Chembiochem. 2006. PMID: 16688706 Free PMC article.

3

Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening.

Schmidt MF, Isidro-Llobet A, Lisurek M, El-Dahshan A, Tan J, Hilgenfeld R, Rademann J. Schmidt MF, et al. Among authors: hilgenfeld r. Angew Chem Int Ed Engl. 2008;47(17):3275-8. doi: 10.1002/anie.200704594. Angew Chem Int Ed Engl. 2008. PMID: 18348134 Free PMC article.

4

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.

Zhu L, George S, Schmidt MF, Al-Gharabli SI, Rademann J, Hilgenfeld R. Zhu L, et al. Among authors: hilgenfeld r. Antiviral Res. 2011 Nov;92(2):204-12. doi: 10.1016/j.antiviral.2011.08.001. Epub 2011 Aug 11. Antiviral Res. 2011. PMID: 21854807 Free PMC article.

5

Picornavirus non-structural proteins as targets for new anti-virals with broad activity.

Norder H, De Palma AM, Selisko B, Costenaro L, Papageorgiou N, Arnan C, Coutard B, Lantez V, De Lamballerie X, Baronti C, Solà M, Tan J, Neyts J, Canard B, Coll M, Gorbalenya AE, Hilgenfeld R. Norder H, et al. Among authors: hilgenfeld r. Antiviral Res. 2011 Mar;89(3):204-18. doi: 10.1016/j.antiviral.2010.12.007. Epub 2011 Jan 12. Antiviral Res. 2011. PMID: 21236302 Review.

6

Crystal structure of the middle domain of human poly(A)-binding protein-interacting protein 1.

Lei J, Mesters JR, von Brunn A, Hilgenfeld R. Lei J, et al. Among authors: hilgenfeld r. Biochem Biophys Res Commun. 2011 May 20;408(4):680-5. doi: 10.1016/j.bbrc.2011.04.088. Epub 2011 Apr 23. Biochem Biophys Res Commun. 2011. PMID: 21539810

7

3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses.

Tan J, George S, Kusov Y, Perbandt M, Anemüller S, Mesters JR, Norder H, Coutard B, Lacroix C, Leyssen P, Neyts J, Hilgenfeld R. Tan J, et al. Among authors: hilgenfeld r. J Virol. 2013 Apr;87(8):4339-51. doi: 10.1128/JVI.01123-12. Epub 2013 Feb 6. J Virol. 2013. PMID: 23388726 Free PMC article.

8

STD-NMR experiments identify a structural motif with novel second-site activity against West Nile virus NS2B-NS3 protease.

Schöne T, Grimm LL, Sakai N, Zhang L, Hilgenfeld R, Peters T. Schöne T, et al. Among authors: hilgenfeld r. Antiviral Res. 2017 Oct;146:174-183. doi: 10.1016/j.antiviral.2017.09.008. Epub 2017 Sep 18. Antiviral Res. 2017. PMID: 28927677

9

The Structure of the Zika Virus Protease, NS2B/NS3^pro.

Hilgenfeld R, Lei J, Zhang L. Hilgenfeld R, et al. Adv Exp Med Biol. 2018;1062:131-145. doi: 10.1007/978-981-10-8727-1_10. Adv Exp Med Biol. 2018. PMID: 29845530 Review.

10

SARS-CoV-2 M^pro inhibitors and activity-based probes for patient-sample imaging.

Rut W, Groborz K, Zhang L, Sun X, Zmudzinski M, Pawlik B, Wang X, Jochmans D, Neyts J, Młynarski W, Hilgenfeld R, Drag M. Rut W, et al. Among authors: hilgenfeld r. Nat Chem Biol. 2021 Feb;17(2):222-228. doi: 10.1038/s41589-020-00689-z. Epub 2020 Oct 22. Nat Chem Biol. 2021. PMID: 33093684

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