Radhakrishnan SK - Search Results

1

Nrf1 can be processed and activated in a proteasome-independent manner.

Vangala JR, Sotzny F, Krüger E, Deshaies RJ, Radhakrishnan SK. Vangala JR, et al. Among authors: radhakrishnan sk. Curr Biol. 2016 Sep 26;26(18):R834-R835. doi: 10.1016/j.cub.2016.08.008. Curr Biol. 2016. PMID: 27676297 Free PMC article.

2

Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells.

Radhakrishnan SK, Lee CS, Young P, Beskow A, Chan JY, Deshaies RJ. Radhakrishnan SK, et al. Mol Cell. 2010 Apr 9;38(1):17-28. doi: 10.1016/j.molcel.2010.02.029. Mol Cell. 2010. PMID: 20385086 Free PMC article.

3

p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition.

Radhakrishnan SK, den Besten W, Deshaies RJ. Radhakrishnan SK, et al. Elife. 2014;3:e01856. doi: 10.7554/eLife.01856. Epub 2014 Jan 21. Elife. 2014. PMID: 24448410 Free PMC article.

4

Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity.

Tomlin FM, Gerling-Driessen UIM, Liu YC, Flynn RA, Vangala JR, Lentz CS, Clauder-Muenster S, Jakob P, Mueller WF, Ordoñez-Rueda D, Paulsen M, Matsui N, Foley D, Rafalko A, Suzuki T, Bogyo M, Steinmetz LM, Radhakrishnan SK, Bertozzi CR. Tomlin FM, et al. Among authors: radhakrishnan sk. ACS Cent Sci. 2017 Nov 22;3(11):1143-1155. doi: 10.1021/acscentsci.7b00224. Epub 2017 Oct 25. ACS Cent Sci. 2017. PMID: 29202016 Free PMC article.

5

Nrf1-mediated transcriptional regulation of the proteasome requires a functional TIP60 complex.

Vangala JR, Radhakrishnan SK. Vangala JR, et al. Among authors: radhakrishnan sk. J Biol Chem. 2019 Feb 8;294(6):2036-2045. doi: 10.1074/jbc.RA118.006290. Epub 2018 Dec 17. J Biol Chem. 2019. PMID: 30559296 Free PMC article.

6

Disabling the Protease DDI2 Attenuates the Transcriptional Activity of NRF1 and Potentiates Proteasome Inhibitor Cytotoxicity.

Northrop A, Vangala JR, Feygin A, Radhakrishnan SK. Northrop A, et al. Among authors: radhakrishnan sk. Int J Mol Sci. 2020 Jan 3;21(1):327. doi: 10.3390/ijms21010327. Int J Mol Sci. 2020. PMID: 31947743 Free PMC article.

7

BET Inhibitors Synergize with Carfilzomib to Induce Cell Death in Cancer Cells via Impairing Nrf1 Transcriptional Activity and Exacerbating the Unfolded Protein Response.

Vangala JR, Potluri A, Radhakrishnan SK. Vangala JR, et al. Among authors: radhakrishnan sk. Biomolecules. 2020 Mar 26;10(4):501. doi: 10.3390/biom10040501. Biomolecules. 2020. PMID: 32224969 Free PMC article.

8

Regulation of NRF1, a master transcription factor of proteasome genes: implications for cancer and neurodegeneration.

Northrop A, Byers HA, Radhakrishnan SK. Northrop A, et al. Among authors: radhakrishnan sk. Mol Biol Cell. 2020 Sep 15;31(20):2158-2163. doi: 10.1091/mbc.E20-04-0238. Mol Biol Cell. 2020. PMID: 32924844 Free PMC article.

9

Trash Talk: Mammalian Proteasome Regulation at the Transcriptional Level.

Kamber Kaya HE, Radhakrishnan SK. Kamber Kaya HE, et al. Among authors: radhakrishnan sk. Trends Genet. 2021 Feb;37(2):160-173. doi: 10.1016/j.tig.2020.09.005. Epub 2020 Sep 25. Trends Genet. 2021. PMID: 32988635 Free PMC article. Review.

10

Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy.

Ward MA, Vangala JR, Kamber Kaya HE, Byers HA, Hosseini N, Diaz A, Cuervo AM, Kaushik S, Radhakrishnan SK. Ward MA, et al. Among authors: radhakrishnan sk. J Cell Biol. 2024 Jun 3;223(6):e202306150. doi: 10.1083/jcb.202306150. Epub 2024 Apr 24. J Cell Biol. 2024. PMID: 38656405 Free PMC article.

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