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Genome-wide association study of plasma resistin levels identified rs1423096 and rs10401670 as possible functional variants in the Japanese population.
Kawamura R, Tabara Y, Tsukada A, Igase M, Ohashi J, Yamada R, Takata Y, Kawamoto R, Saito I, Onuma H, Tanigawa T, Yamada K, Kato N, Ohyagi Y, Miki T, Kohara K, Osawa H. Kawamura R, et al. Among authors: yamada k, yamada r. Physiol Genomics. 2016 Nov 1;48(11):874-881. doi: 10.1152/physiolgenomics.00040.2016. Epub 2016 Sep 23. Physiol Genomics. 2016. PMID: 27664181
Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population.
Osawa H, Tabara Y, Kawamoto R, Ohashi J, Ochi M, Onuma H, Nishida W, Yamada K, Nakura J, Kohara K, Miki T, Makino H. Osawa H, et al. Among authors: yamada k. Diabetes Care. 2007 Jun;30(6):1501-6. doi: 10.2337/dc06-1936. Epub 2007 Mar 23. Diabetes Care. 2007. PMID: 17384338
The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3.
Osawa H, Yamada K, Onuma H, Murakami A, Ochi M, Kawata H, Nishimiya T, Niiya T, Shimizu I, Nishida W, Hashiramoto M, Kanatsuka A, Fujii Y, Ohashi J, Makino H. Osawa H, et al. Among authors: yamada k. Am J Hum Genet. 2004 Oct;75(4):678-86. doi: 10.1086/424761. Epub 2004 Aug 26. Am J Hum Genet. 2004. PMID: 15338456 Free PMC article.
Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes.
Osawa H, Onuma H, Ochi M, Murakami A, Yamauchi J, Takasuka T, Tanabe F, Shimizu I, Kato K, Nishida W, Yamada K, Tabara Y, Yasukawa M, Fujii Y, Ohashi J, Miki T, Makino H. Osawa H, et al. Among authors: yamada k. Biochem Biophys Res Commun. 2005 Sep 23;335(2):596-602. doi: 10.1016/j.bbrc.2005.07.122. Biochem Biophys Res Commun. 2005. PMID: 16087164
The G/G genotype of a single nucleotide polymorphism at -1066 of c-Jun N-terminal kinase 1 gene (MAPK8) does not affect type 2 diabetes susceptibility despite the specific binding of AP2alpha.
Osawa H, Yamada K, Tabara Y, Ochi M, Onuma H, Nishida W, Shimizu I, Kawamoto R, Fujii Y, Miki T, Ohashi J, Makino H. Osawa H, et al. Among authors: yamada k. Clin Endocrinol (Oxf). 2008 Jul;69(1):36-44. doi: 10.1111/j.1365-2265.2007.03143.x. Epub 2008 Jul 1. Clin Endocrinol (Oxf). 2008. PMID: 18036196
Systematic search for single nucleotide polymorphisms in the 5' flanking region of the human phosphodiesterase 3B gene: absence of evidence for major effects of identified polymorphisms on susceptibility to Japanese type 2 diabetes.
Osawa H, Niiya T, Onuma H, Murakami A, Ochi M, Nishimiya T, Ogura T, Kato K, Shimizu I, Fujii Y, Ohashi J, Yamada K, Liang SJ, Manganiello VC, Fujita-Yamaguchi Y, Makino H. Osawa H, et al. Among authors: yamada k. Mol Genet Metab. 2003 May;79(1):43-51. doi: 10.1016/s1096-7192(03)00035-0. Mol Genet Metab. 2003. PMID: 12765845
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