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Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant.
Wang RE, Wang Y, Zhang Y, Gabrelow C, Zhang Y, Chi V, Fu Q, Luo X, Wang D, Joseph S, Johnson K, Chatterjee AK, Wright TM, Nguyen-Tran VT, Teijaro J, Theofilopoulos AN, Schultz PG, Wang F. Wang RE, et al. Among authors: zhang y. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11501-11506. doi: 10.1073/pnas.1612803113. Epub 2016 Sep 23. Proc Natl Acad Sci U S A. 2016. PMID: 27663736 Free PMC article.
Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation.
Wang F, Sen S, Zhang Y, Ahmad I, Zhu X, Wilson IA, Smider VV, Magliery TJ, Schultz PG. Wang F, et al. Among authors: zhang y. Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4261-6. doi: 10.1073/pnas.1301810110. Epub 2013 Feb 25. Proc Natl Acad Sci U S A. 2013. Retraction in: Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7855. doi: 10.1073/pnas.1712805114 PMID: 23440204 Free PMC article. Retracted.
Reshaping antibody diversity.
Wang F, Ekiert DC, Ahmad I, Yu W, Zhang Y, Bazirgan O, Torkamani A, Raudsepp T, Mwangi W, Criscitiello MF, Wilson IA, Schultz PG, Smider VV. Wang F, et al. Among authors: zhang y. Cell. 2013 Jun 6;153(6):1379-93. doi: 10.1016/j.cell.2013.04.049. Cell. 2013. PMID: 23746848 Free PMC article.
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis.
Wang F, Sambandan D, Halder R, Wang J, Batt SM, Weinrick B, Ahmad I, Yang P, Zhang Y, Kim J, Hassani M, Huszar S, Trefzer C, Ma Z, Kaneko T, Mdluli KE, Franzblau S, Chatterjee AK, Johnsson K, Mikusova K, Besra GS, Fütterer K, Robbins SH, Barnes SW, Walker JR, Jacobs WR Jr, Schultz PG. Wang F, et al. Among authors: zhang y. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2510-7. doi: 10.1073/pnas.1309171110. Epub 2013 Jun 17. Proc Natl Acad Sci U S A. 2013. PMID: 23776209 Free PMC article.
An antibody CDR3-erythropoietin fusion protein.
Zhang Y, Wang D, Welzel G, Wang Y, Schultz PG, Wang F. Zhang Y, et al. ACS Chem Biol. 2013 Oct 18;8(10):2117-21. doi: 10.1021/cb4004749. Epub 2013 Aug 14. ACS Chem Biol. 2013. PMID: 23941200 Free PMC article.
An antibody with a variable-region coiled-coil "knob" domain.
Zhang Y, Goswami D, Wang D, Wang TS, Sen S, Magliery TJ, Griffin PR, Wang F, Schultz PG. Zhang Y, et al. Angew Chem Int Ed Engl. 2014 Jan 3;53(1):132-5. doi: 10.1002/anie.201307939. Epub 2013 Nov 19. Angew Chem Int Ed Engl. 2014. PMID: 24254636 Free PMC article.
Rational design of humanized dual-agonist antibodies.
Zhang Y, Liu Y, Wang Y, Schultz PG, Wang F. Zhang Y, et al. J Am Chem Soc. 2015 Jan 14;137(1):38-41. doi: 10.1021/ja510519u. Epub 2014 Dec 24. J Am Chem Soc. 2015. PMID: 25494484
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