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Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.
Ojo KK, Ranade RM, Zhang Z, Dranow DM, Myers JB, Choi R, Nakazawa Hewitt S, Edwards TE, Davies DR, Lorimer D, Boyle SM, Barrett LK, Buckner FS, Fan E, Van Voorhis WC. Ojo KK, et al. Among authors: ranade rm. PLoS One. 2016 Aug 8;11(8):e0160350. doi: 10.1371/journal.pone.0160350. eCollection 2016. PLoS One. 2016. PMID: 27500735 Free PMC article.
Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection.
Buckner FS, Ranade RM, Gillespie JR, Shibata S, Hulverson MA, Zhang Z, Huang W, Choi R, Verlinde CLMJ, Hol WGJ, Ochida A, Akao Y, Choy RKM, Van Voorhis WC, Arnold SLM, Jumani RS, Huston CD, Fan E. Buckner FS, et al. Among authors: ranade rm. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02061-18. doi: 10.1128/AAC.02061-18. Print 2019 Apr. Antimicrob Agents Chemother. 2019. PMID: 30745384 Free PMC article.
The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.
Barros-Álvarez X, Turley S, Ranade RM, Gillespie JR, Duster NA, Verlinde CLMJ, Fan E, Buckner FS, Hol WGJ. Barros-Álvarez X, et al. Among authors: ranade rm. Acta Crystallogr F Struct Biol Commun. 2018 Apr 1;74(Pt 4):245-254. doi: 10.1107/S2053230X18003151. Epub 2018 Mar 28. Acta Crystallogr F Struct Biol Commun. 2018. PMID: 29633973 Free PMC article.
Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness.
Koh CY, Kim JE, Wetzel AB, de van der Schueren WJ, Shibata S, Ranade RM, Liu J, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG. Koh CY, et al. Among authors: ranade rm. PLoS Negl Trop Dis. 2014 Apr 17;8(4):e2775. doi: 10.1371/journal.pntd.0002775. eCollection 2014 Apr. PLoS Negl Trop Dis. 2014. PMID: 24743796 Free PMC article.
Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.
Huang W, Zhang Z, Barros-Álvarez X, Koh CY, Ranade RM, Gillespie JR, Creason SA, Shibata S, Verlinde CLMJ, Hol WGJ, Buckner FS, Fan E. Huang W, et al. Among authors: ranade rm. Eur J Med Chem. 2016 Nov 29;124:1081-1092. doi: 10.1016/j.ejmech.2016.10.024. Epub 2016 Oct 14. Eur J Med Chem. 2016. PMID: 27788467 Free PMC article.
Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections.
Faghih O, Zhang Z, Ranade RM, Gillespie JR, Creason SA, Huang W, Shibata S, Barros-Álvarez X, Verlinde CLMJ, Hol WGJ, Fan E, Buckner FS. Faghih O, et al. Among authors: ranade rm. Antimicrob Agents Chemother. 2017 Oct 24;61(11):e00999-17. doi: 10.1128/AAC.00999-17. Print 2017 Nov. Antimicrob Agents Chemother. 2017. PMID: 28848016 Free PMC article.
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