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iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy.
Kodo K, Ong SG, Jahanbani F, Termglinchan V, Hirono K, InanlooRahatloo K, Ebert AD, Shukla P, Abilez OJ, Churko JM, Karakikes I, Jung G, Ichida F, Wu SM, Snyder MP, Bernstein D, Wu JC. Kodo K, et al. Among authors: bernstein d. Nat Cell Biol. 2016 Oct;18(10):1031-42. doi: 10.1038/ncb3411. Epub 2016 Sep 19. Nat Cell Biol. 2016. PMID: 27642787 Free PMC article.
Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy.
Mourkioti F, Kustan J, Kraft P, Day JW, Zhao MM, Kost-Alimova M, Protopopov A, DePinho RA, Bernstein D, Meeker AK, Blau HM. Mourkioti F, et al. Among authors: bernstein d. Nat Cell Biol. 2013 Aug;15(8):895-904. doi: 10.1038/ncb2790. Epub 2013 Jul 7. Nat Cell Biol. 2013. PMID: 23831727 Free PMC article.
hiPSC Modeling of Inherited Cardiomyopathies.
Jung G, Bernstein D. Jung G, et al. Among authors: bernstein d. Curr Treat Options Cardiovasc Med. 2014 Jul;16(7):320. doi: 10.1007/s11936-014-0320-7. Curr Treat Options Cardiovasc Med. 2014. PMID: 24838688 Free PMC article.
A long noncoding RNA protects the heart from pathological hypertrophy.
Han P, Li W, Lin CH, Yang J, Shang C, Nuernberg ST, Jin KK, Xu W, Lin CY, Lin CJ, Xiong Y, Chien H, Zhou B, Ashley E, Bernstein D, Chen PS, Chen HV, Quertermous T, Chang CP. Han P, et al. Among authors: bernstein d. Nature. 2014 Oct 2;514(7520):102-106. doi: 10.1038/nature13596. Epub 2014 Aug 10. Nature. 2014. PMID: 25119045 Free PMC article.
RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension.
Rhodes CJ, Im H, Cao A, Hennigs JK, Wang L, Sa S, Chen PI, Nickel NP, Miyagawa K, Hopper RK, Tojais NF, Li CG, Gu M, Spiekerkoetter E, Xian Z, Chen R, Zhao M, Kaschwich M, Del Rosario PA, Bernstein D, Zamanian RT, Wu JC, Snyder MP, Rabinovitch M. Rhodes CJ, et al. Among authors: bernstein d. Am J Respir Crit Care Med. 2015 Aug 1;192(3):356-66. doi: 10.1164/rccm.201408-1528OC. Am J Respir Crit Care Med. 2015. PMID: 26030479 Free PMC article.
Time-dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell-derived cardiomyocytes and induced maturation with biomechanical stimulation.
Jung G, Fajardo G, Ribeiro AJ, Kooiker KB, Coronado M, Zhao M, Hu DQ, Reddy S, Kodo K, Sriram K, Insel PA, Wu JC, Pruitt BL, Bernstein D. Jung G, et al. Among authors: bernstein d. FASEB J. 2016 Apr;30(4):1464-79. doi: 10.1096/fj.15-280982. Epub 2015 Dec 16. FASEB J. 2016. PMID: 26675706 Free PMC article.
In "early" hiPSC-CMs (less than or equal to d 30), beta2-ARs are a primary source of cAMP/PKA signaling. With longer culture, beta1-AR signaling increases: from 0% of cAMP generation at d 30 to 56.8 6.6% by d 60. ...S., Kooiker, K. B., Coronado, M., Zhao, M., …
In "early" hiPSC-CMs (less than or equal to d 30), beta2-ARs are a primary source of cAMP/PKA signaling. With longer culture, beta1-A …
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC. Burridge PW, et al. Among authors: bernstein d. Nat Med. 2016 May;22(5):547-56. doi: 10.1038/nm.4087. Epub 2016 Apr 18. Nat Med. 2016. PMID: 27089514 Free PMC article.
Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice.
Chennamsetty I, Coronado M, Contrepois K, Keller MP, Carcamo-Orive I, Sandin J, Fajardo G, Whittle AJ, Fathzadeh M, Snyder M, Reaven G, Attie AD, Bernstein D, Quertermous T, Knowles JW. Chennamsetty I, et al. Among authors: bernstein d. Cell Rep. 2016 Oct 4;17(2):527-540. doi: 10.1016/j.celrep.2016.09.005. Cell Rep. 2016. PMID: 27705799 Free PMC article.
1,917 results