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Page 1
Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 2.
Tsuno N, Yukimasa A, Yoshida O, Suzuki S, Nakai H, Ogawa T, Fujiu M, Takaya K, Nozu A, Yamaguchi H, Matsuda H, Funaki S, Nishimura Y, Ito T, Nagamatsu D, Asaki T, Horita N, Yamamoto M, Hinata M, Soga M, Imai M, Morioka Y, Kanemasa T, Sakaguchi G, Iso Y. Tsuno N, et al. Bioorg Med Chem Lett. 2016 Oct 15;26(20):4936-4941. doi: 10.1016/j.bmcl.2016.09.014. Epub 2016 Sep 7. Bioorg Med Chem Lett. 2016. PMID: 27634196
Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 1.
Tsuno N, Yukimasa A, Yoshida O, Ichihashi Y, Inoue T, Ueno T, Yamaguchi H, Matsuda H, Funaki S, Yamanada N, Tanimura M, Nagamatsu D, Nishimura Y, Ito T, Soga M, Horita N, Yamamoto M, Hinata M, Imai M, Morioka Y, Kanemasa T, Sakaguchi G, Iso Y. Tsuno N, et al. Bioorg Med Chem Lett. 2016 Oct 15;26(20):4930-4935. doi: 10.1016/j.bmcl.2016.09.013. Epub 2016 Sep 7. Bioorg Med Chem Lett. 2016. PMID: 27637151
Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain.
Tsuno N, Yukimasa A, Yoshida O, Suzuki S, Nakai H, Ogawa T, Fujiu M, Takaya K, Nozu A, Yamaguchi H, Matsuda H, Funaki S, Yamanada N, Tanimura M, Nagamatsu D, Asaki T, Horita N, Yamamoto M, Hinata M, Soga M, Imai M, Morioka Y, Kanemasa T, Sakaguchi G, Iso Y. Tsuno N, et al. Bioorg Med Chem. 2017 Apr 1;25(7):2177-2190. doi: 10.1016/j.bmc.2017.02.047. Epub 2017 Mar 1. Bioorg Med Chem. 2017. PMID: 28284871
Structure-activity relationship studies and discovery of a potent transient receptor potential vanilloid (TRPV1) antagonist 4-[3-chloro-5-[(1S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxamide (V116517) as a clinical candidate for pain management.
Tafesse L, Kanemasa T, Kurose N, Yu J, Asaki T, Wu G, Iwamoto Y, Yamaguchi Y, Ni C, Engel J, Tsuno N, Patel A, Zhou X, Shintani T, Brown K, Hasegawa T, Shet M, Iso Y, Kato A, Kyle DJ. Tafesse L, et al. Among authors: tsuno n. J Med Chem. 2014 Aug 14;57(15):6781-94. doi: 10.1021/jm500818a. Epub 2014 Aug 1. J Med Chem. 2014. PMID: 25057800
International Forum on Blood Donation in Individuals with Current, Past or Germline Predisposition to Malignancy: Responses.
Baggio D, Fox LC, Wood EM, Aditya RN, Goldman M, van den Berg K, Kayser S, Wuchter P, Namba N, Tsuno NH, Makino S, Lee CK, Akhtar N, Shah F, Miflin G, Prati D, La Raja M, Rocca U, Richard P, Tiberghien P, Harley RJ, Raouf MY, Sharma R, Kaur S, Bruijns S, Prakke-Weekamp H, Dunbar N. Baggio D, et al. Among authors: tsuno nh. Vox Sang. 2023 Dec;118(12):1122-1144. doi: 10.1111/vox.13550. Epub 2023 Nov 15. Vox Sang. 2023. PMID: 37966022 No abstract available.
196 results