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Page 1
Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 2.
Tsuno N, Yukimasa A, Yoshida O, Suzuki S, Nakai H, Ogawa T, Fujiu M, Takaya K, Nozu A, Yamaguchi H, Matsuda H, Funaki S, Nishimura Y, Ito T, Nagamatsu D, Asaki T, Horita N, Yamamoto M, Hinata M, Soga M, Imai M, Morioka Y, Kanemasa T, Sakaguchi G, Iso Y. Tsuno N, et al. Among authors: takaya k. Bioorg Med Chem Lett. 2016 Oct 15;26(20):4936-4941. doi: 10.1016/j.bmcl.2016.09.014. Epub 2016 Sep 7. Bioorg Med Chem Lett. 2016. PMID: 27634196
Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain.
Tsuno N, Yukimasa A, Yoshida O, Suzuki S, Nakai H, Ogawa T, Fujiu M, Takaya K, Nozu A, Yamaguchi H, Matsuda H, Funaki S, Yamanada N, Tanimura M, Nagamatsu D, Asaki T, Horita N, Yamamoto M, Hinata M, Soga M, Imai M, Morioka Y, Kanemasa T, Sakaguchi G, Iso Y. Tsuno N, et al. Among authors: takaya k. Bioorg Med Chem. 2017 Apr 1;25(7):2177-2190. doi: 10.1016/j.bmc.2017.02.047. Epub 2017 Mar 1. Bioorg Med Chem. 2017. PMID: 28284871
Discovery of novel 5-hydroxy-4-pyridone-3-carboxy acids as potent inhibitors of influenza Cap-dependent endonuclease.
Miyagawa M, Akiyama T, Mikamiyama-Iwata M, Hattori K, Kurihara N, Taoda Y, Takahashi-Kageyama C, Kurose N, Mikamiyama H, Suzuki N, Takaya K, Tomita K, Matsuo K, Morimoto K, Yoshida R, Shishido T, Yoshinaga T, Sato A, Kawai M. Miyagawa M, et al. Among authors: takaya k. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4739-4742. doi: 10.1016/j.bmcl.2016.08.038. Epub 2016 Aug 18. Bioorg Med Chem Lett. 2016. PMID: 27568084
Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction.
Juncosa JI, Takaya K, Le HV, Moschitto MJ, Weerawarna PM, Mascarenhas R, Liu D, Dewey SL, Silverman RB. Juncosa JI, et al. Among authors: takaya k. J Am Chem Soc. 2018 Feb 14;140(6):2151-2164. doi: 10.1021/jacs.7b10965. Epub 2018 Jan 30. J Am Chem Soc. 2018. PMID: 29381352 Free PMC article.
Novel integrated multiomics analysis reveals a key role for integrin beta-like 1 in wound scarring.
Kim SE, Noda R, Liu YC, Nakajima Y, Kameoka S, Motooka D, Mizuno S, Takahashi S, Takaya K, Murase T, Ikematsu K, Tratsiakova K, Motoyama T, Nakashima M, Kishi K, Martin P, Seno S, Okuzaki D, Mori R. Kim SE, et al. Among authors: takaya k. EMBO Rep. 2025 Jan;26(1):122-152. doi: 10.1038/s44319-024-00322-3. Epub 2024 Nov 18. EMBO Rep. 2025. PMID: 39558136 Free article.
231 results