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Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses.
Kirkegaard T, Gray J, Priestman DA, Wallom KL, Atkins J, Olsen OD, Klein A, Drndarski S, Petersen NH, Ingemann L, Smith DA, Morris L, Bornæs C, Jørgensen SH, Williams I, Hinsby A, Arenz C, Begley D, Jäättelä M, Platt FM. Kirkegaard T, et al. Sci Transl Med. 2016 Sep 7;8(355):355ra118. doi: 10.1126/scitranslmed.aad9823. Sci Transl Med. 2016. PMID: 27605553 Free PMC article.
Lysosomal involvement in cell death and cancer.
Kirkegaard T, Jäättelä M. Kirkegaard T, et al. Biochim Biophys Acta. 2009 Apr;1793(4):746-54. doi: 10.1016/j.bbamcr.2008.09.008. Epub 2008 Oct 2. Biochim Biophys Acta. 2009. PMID: 18948147 Free article. Review.
BAMLET activates a lysosomal cell death program in cancer cells.
Rammer P, Groth-Pedersen L, Kirkegaard T, Daugaard M, Rytter A, Szyniarowski P, Høyer-Hansen M, Povlsen LK, Nylandsted J, Larsen JE, Jäättelä M. Rammer P, et al. Among authors: kirkegaard t. Mol Cancer Ther. 2010 Jan;9(1):24-32. doi: 10.1158/1535-7163.MCT-09-0559. Epub 2010 Jan 6. Mol Cancer Ther. 2010. PMID: 20053771
Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase.
Petersen NH, Olsen OD, Groth-Pedersen L, Ellegaard AM, Bilgin M, Redmer S, Ostenfeld MS, Ulanet D, Dovmark TH, Lønborg A, Vindeløv SD, Hanahan D, Arenz C, Ejsing CS, Kirkegaard T, Rohde M, Nylandsted J, Jäättelä M. Petersen NH, et al. Among authors: kirkegaard t. Cancer Cell. 2013 Sep 9;24(3):379-93. doi: 10.1016/j.ccr.2013.08.003. Cancer Cell. 2013. PMID: 24029234 Free article.
Human heat shock protein 70 (Hsp70) as a peripheral membrane protein.
Mahalka AK, Kirkegaard T, Jukola LT, Jäättelä M, Kinnunen PK. Mahalka AK, et al. Among authors: kirkegaard t. Biochim Biophys Acta. 2014 May;1838(5):1344-61. doi: 10.1016/j.bbamem.2014.01.022. Epub 2014 Jan 28. Biochim Biophys Acta. 2014. PMID: 24480410 Free article.
74 results