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Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses.
Kirkegaard T, Gray J, Priestman DA, Wallom KL, Atkins J, Olsen OD, Klein A, Drndarski S, Petersen NH, Ingemann L, Smith DA, Morris L, Bornæs C, Jørgensen SH, Williams I, Hinsby A, Arenz C, Begley D, Jäättelä M, Platt FM. Kirkegaard T, et al. Among authors: jaattela m. Sci Transl Med. 2016 Sep 7;8(355):355ra118. doi: 10.1126/scitranslmed.aad9823. Sci Transl Med. 2016. PMID: 27605553 Free PMC article.
Lysosomal involvement in cell death and cancer.
Kirkegaard T, Jäättelä M. Kirkegaard T, et al. Among authors: jaattela m. Biochim Biophys Acta. 2009 Apr;1793(4):746-54. doi: 10.1016/j.bbamcr.2008.09.008. Epub 2008 Oct 2. Biochim Biophys Acta. 2009. PMID: 18948147 Free article. Review.
BAMLET activates a lysosomal cell death program in cancer cells.
Rammer P, Groth-Pedersen L, Kirkegaard T, Daugaard M, Rytter A, Szyniarowski P, Høyer-Hansen M, Povlsen LK, Nylandsted J, Larsen JE, Jäättelä M. Rammer P, et al. Among authors: jaattela m. Mol Cancer Ther. 2010 Jan;9(1):24-32. doi: 10.1158/1535-7163.MCT-09-0559. Epub 2010 Jan 6. Mol Cancer Ther. 2010. PMID: 20053771
LEDGF (p75) promotes DNA-end resection and homologous recombination.
Daugaard M, Baude A, Fugger K, Povlsen LK, Beck H, Sørensen CS, Petersen NH, Sorensen PH, Lukas C, Bartek J, Lukas J, Rohde M, Jäättelä M. Daugaard M, et al. Among authors: jaattela m. Nat Struct Mol Biol. 2012 Aug;19(8):803-10. doi: 10.1038/nsmb.2314. Epub 2012 Jul 8. Nat Struct Mol Biol. 2012. PMID: 22773103
Cancer-associated lysosomal changes: friends or foes?
Kallunki T, Olsen OD, Jäättelä M. Kallunki T, et al. Among authors: jaattela m. Oncogene. 2013 Apr 18;32(16):1995-2004. doi: 10.1038/onc.2012.292. Epub 2012 Jul 9. Oncogene. 2013. PMID: 22777359 Review.
209 results