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Page 1
Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.
Nishizawa N, Takatsu Y, Kumano S, Kiba A, Ban J, Tsutsumi S, Matsui H, Matsumoto SI, Yamaguchi M, Ikeda Y, Kusaka M, Ohtaki T, Itoh F, Asami T. Nishizawa N, et al. Among authors: kumano s. J Med Chem. 2016 Oct 13;59(19):8804-8811. doi: 10.1021/acs.jmedchem.6b00379. Epub 2016 Sep 21. J Med Chem. 2016. PMID: 27589480
Chronic administration of the metastin/kisspeptin analog KISS1-305 or the investigational agent TAK-448 suppresses hypothalamic pituitary gonadal function and depletes plasma testosterone in adult male rats.
Matsui H, Tanaka A, Yokoyama K, Takatsu Y, Ishikawa K, Asami T, Nishizawa N, Suzuki A, Kumano S, Terada M, Kusaka M, Kitada C, Ohtaki T. Matsui H, et al. Among authors: kumano s. Endocrinology. 2012 Nov;153(11):5297-308. doi: 10.1210/en.2012-1388. Epub 2012 Oct 1. Endocrinology. 2012. PMID: 23027808
Pharmacologic profiles of investigational kisspeptin/metastin analogues, TAK-448 and TAK-683, in adult male rats in comparison to the GnRH analogue leuprolide.
Matsui H, Masaki T, Akinaga Y, Kiba A, Takatsu Y, Nakata D, Tanaka A, Ban J, Matsumoto S, Kumano S, Suzuki A, Ikeda Y, Yamaguchi M, Watanabe T, Ohtaki T, Kusaka M. Matsui H, et al. Among authors: kumano s. Eur J Pharmacol. 2014 Jul 15;735:77-85. doi: 10.1016/j.ejphar.2014.03.058. Epub 2014 Apr 18. Eur J Pharmacol. 2014. PMID: 24747751
Highly potent antiobesity effect of a short-length peptide YY analog in mice.
Nishizawa N, Niida A, Adachi Y, Kanematsu-Yamaki Y, Masuda Y, Kumano S, Yokoyama K, Noguchi Y, Asakawa T, Hirabayashi H, Amano N, Takekawa S, Ohtaki T, Asami T. Nishizawa N, et al. Among authors: kumano s. Bioorg Med Chem. 2017 Oct 15;25(20):5718-5725. doi: 10.1016/j.bmc.2017.08.044. Epub 2017 Sep 1. Bioorg Med Chem. 2017. PMID: 28917449
A Short-Length Peptide YY Analogue with Anorectic Effect in Mice.
Nishizawa N, Niida A, Masuda Y, Kumano S, Yokoyama K, Hirabayashi H, Amano N, Ohtaki T, Asami T. Nishizawa N, et al. Among authors: kumano s. ACS Omega. 2017 May 31;2(5):2200-2207. doi: 10.1021/acsomega.7b00258. Epub 2017 May 18. ACS Omega. 2017. PMID: 30023658 Free PMC article.
137 results