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Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering.
Gu C, Lamb ML, Johannes JW, Sylvester MA, Eisman MS, Harrison RA, Hu H, Kazmirski S, Mikule K, Peng B, Su N, Wang W, Ye Q, Zheng X, Lyne PD, Scott DA. Gu C, et al. Among authors: harrison ra. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4775-4780. doi: 10.1016/j.bmcl.2016.08.030. Epub 2016 Aug 12. Bioorg Med Chem Lett. 2016. PMID: 27578247
Developing and applying a training needs analysis tool for healthcare workers managing snakebite envenoming: A cross-sectional study in Eswatini.
Steinhorst J, Baker C, Padidar S, Litschka-Koen T, Ngwenya E, Mmema L, Thomas B, Shongwe N, Sithole T, Mathobela M, Trelfa A, Casewell NR, Lalloo DG, Harrison RA, Pons J, Stienstra Y. Steinhorst J, et al. Among authors: harrison ra. PLoS Negl Trop Dis. 2025 Jan 8;19(1):e0012778. doi: 10.1371/journal.pntd.0012778. eCollection 2025 Jan. PLoS Negl Trop Dis. 2025. PMID: 39776319 Free PMC article.
Intraspecific venom variation in the medically important puff adder (Bitis arietans): Comparative venom gland transcriptomics, in vitro venom activity and immunological recognition by antivenom.
Dawson CA, Bartlett KE, Wilkinson MC, Ainsworth S, Albulescu LO, Kazandijan T, Hall SR, Westhorpe A, Clare R, Wagstaff S, Modahl CM, Harrison RA, Casewell NR. Dawson CA, et al. Among authors: harrison ra. PLoS Negl Trop Dis. 2024 Oct 18;18(10):e0012570. doi: 10.1371/journal.pntd.0012570. eCollection 2024 Oct. PLoS Negl Trop Dis. 2024. PMID: 39423239 Free PMC article.
A Randomized Controlled Trial to Optimize Antivenom Therapy for Carpet Viper (Echis romani)-Envenomed Children in Nigeria.
Hamman NA, Ibrahim AD, Hamza M, Jahun MG, Micah M, Lawal HA, Abubakar SB, Iliyasu G, Chedi BAZ, Mohammed I, Harrison RA, Gutiérrez JM, Habib AG. Hamman NA, et al. Among authors: harrison ra. Am J Trop Med Hyg. 2024 Aug 6;111(4):904-910. doi: 10.4269/ajtmh.24-0222. Print 2024 Oct 2. Am J Trop Med Hyg. 2024. PMID: 39106853 Clinical Trial.
Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib.
Bartlett KE, Hall SR, Rasmussen SA, Crittenden E, Dawson CA, Albulescu LO, Laprade W, Harrison RA, Saviola AJ, Modahl CM, Jenkins TP, Wilkinson MC, Gutiérrez JM, Casewell NR. Bartlett KE, et al. Among authors: harrison ra. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2315597121. doi: 10.1073/pnas.2315597121. Epub 2024 Apr 30. Proc Natl Acad Sci U S A. 2024. PMID: 38687786 Free PMC article.
444 results