Oldfield E - Search Results

1

Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth.

Desai J, Wang Y Dr, Wang K Dr, Malwal SR Dr, Oldfield E. Desai J, et al. Among authors: oldfield e. ChemMedChem. 2016 Oct 6;11(19):2205-2215. doi: 10.1002/cmdc.201600343. Epub 2016 Aug 30. ChemMedChem. 2016. PMID: 27571880 Free PMC article.

2

Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin.

Leon A, Liu L, Yang Y, Hudock MP, Hall P, Yin F, Studer D, Puan KJ, Morita CT, Oldfield E. Leon A, et al. Among authors: oldfield e. J Med Chem. 2006 Dec 14;49(25):7331-41. doi: 10.1021/jm060492b. J Med Chem. 2006. PMID: 17149863

3

Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.

Song Y, Lin FY, Yin F, Hensler M, Rodrígues Poveda CA, Mukkamala D, Cao R, Wang H, Morita CT, González Pacanowska D, Nizet V, Oldfield E. Song Y, et al. Among authors: oldfield e. J Med Chem. 2009 Feb 26;52(4):976-88. doi: 10.1021/jm801023u. J Med Chem. 2009. PMID: 19191557 Free PMC article.

4

Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.

Song Y, Liu CI, Lin FY, No JH, Hensler M, Liu YL, Jeng WY, Low J, Liu GY, Nizet V, Wang AH, Oldfield E. Song Y, et al. Among authors: oldfield e. J Med Chem. 2009 Jul 9;52(13):3869-80. doi: 10.1021/jm9001764. J Med Chem. 2009. PMID: 19456099 Free PMC article.

5

Thermodynamics of bisphosphonates binding to human bone: a two-site model.

Mukherjee S, Huang C, Guerra F, Wang K, Oldfield E. Mukherjee S, et al. Among authors: oldfield e. J Am Chem Soc. 2009 Jun 24;131(24):8374-5. doi: 10.1021/ja902895p. J Am Chem Soc. 2009. PMID: 19489581 Free PMC article.

6

Bioorganometallic mechanism of action, and inhibition, of IspH.

Wang W, Wang K, Liu YL, No JH, Li J, Nilges MJ, Oldfield E. Wang W, et al. Among authors: oldfield e. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4522-7. doi: 10.1073/pnas.0911087107. Epub 2010 Feb 19. Proc Natl Acad Sci U S A. 2010. PMID: 20173096 Free PMC article.

7

Inhibition of the Fe(4)S(4)-cluster-containing protein IspH (LytB): electron paramagnetic resonance, metallacycles, and mechanisms.

Wang K, Wang W, No JH, Zhang Y, Zhang Y, Oldfield E. Wang K, et al. Among authors: oldfield e. J Am Chem Soc. 2010 May 19;132(19):6719-27. doi: 10.1021/ja909664j. J Am Chem Soc. 2010. PMID: 20426416 Free PMC article.

8

Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG).

Wang W, Li J, Wang K, Huang C, Zhang Y, Oldfield E. Wang W, et al. Among authors: oldfield e. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11189-93. doi: 10.1073/pnas.1000264107. Epub 2010 Jun 7. Proc Natl Acad Sci U S A. 2010. PMID: 20534554 Free PMC article.

9

Targeting isoprenoid biosynthesis for drug discovery: bench to bedside.

Oldfield E. Oldfield E. Acc Chem Res. 2010 Sep 21;43(9):1216-26. doi: 10.1021/ar100026v. Acc Chem Res. 2010. PMID: 20560544 Free PMC article.

10

Diterpene cyclases and the nature of the isoprene fold.

Cao R, Zhang Y, Mann FM, Huang C, Mukkamala D, Hudock MP, Mead ME, Prisic S, Wang K, Lin FY, Chang TK, Peters RJ, Oldfield E. Cao R, et al. Among authors: oldfield e. Proteins. 2010 Aug 15;78(11):2417-32. doi: 10.1002/prot.22751. Proteins. 2010. PMID: 20602361 Free PMC article.

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