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A Semi-Mechanistic Population Pharmacokinetic Model of Nusinersen: An Antisense Oligonucleotide for the Treatment of Spinal Muscular Atrophy.
Biliouris K, Gaitonde P, Yin W, Norris DA, Wang Y, Henry S, Fey R, Nestorov I, Schmidt S, Rogge M, Lesko LJ, Trame MN. Biliouris K, et al. Among authors: lesko lj. CPT Pharmacometrics Syst Pharmacol. 2018 Sep;7(9):581-592. doi: 10.1002/psp4.12323. Epub 2018 Aug 16. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 30043511 Free PMC article.
Systems pharmacology to predict drug safety in drug development.
Trame MN, Biliouris K, Lesko LJ, Mettetal JT. Trame MN, et al. Among authors: lesko lj. Eur J Pharm Sci. 2016 Oct 30;94:93-95. doi: 10.1016/j.ejps.2016.05.027. Epub 2016 May 29. Eur J Pharm Sci. 2016. PMID: 27251780 Review.
Regulatory Perspectives in Pharmacometric Models of Osteoporosis.
Madrasi K, Li F, Kim MJ, Samant S, Voss S, Kehoe T, Bashaw ED, Ahn HY, Wang Y, Florian J, Schmidt S, Lesko LJ, Li L. Madrasi K, et al. Among authors: lesko lj. J Clin Pharmacol. 2018 May;58(5):572-585. doi: 10.1002/jcph.1071. Epub 2018 Feb 27. J Clin Pharmacol. 2018. PMID: 29485684 Review.
Is Bioequivalence Established Based on the Reference-Scaled Average Bioequivalence Approach Relevant to Chronic Administration of Phenytoin? Perspectives Based on Population Pharmacokinetic Modeling and Simulations.
Kim H, Fang L, Yu J, Meng Z, Trame MN, Schmidt S, Lesko LJ, Zhao L. Kim H, et al. Among authors: lesko lj. J Clin Pharmacol. 2019 Aug;59(8):1061-1069. doi: 10.1002/jcph.1380. Epub 2019 Feb 4. J Clin Pharmacol. 2019. PMID: 30716169 Clinical Trial.
218 results