Lewis AK - Search Results

1

Oxidation increases the strength of the methionine-aromatic interaction.

Lewis AK, Dunleavy KM, Senkow TL, Her C, Horn BT, Jersett MA, Mahling R, McCarthy MR, Perell GT, Valley CC, Karim CB, Gao J, Pomerantz WC, Thomas DD, Cembran A, Hinderliter A, Sachs JN. Lewis AK, et al. Nat Chem Biol. 2016 Oct;12(10):860-6. doi: 10.1038/nchembio.2159. Epub 2016 Aug 22. Nat Chem Biol. 2016. PMID: 27547920 Free PMC article.

2

The methionine-aromatic motif plays a unique role in stabilizing protein structure.

Valley CC, Cembran A, Perlmutter JD, Lewis AK, Labello NP, Gao J, Sachs JN. Valley CC, et al. Among authors: lewis ak. J Biol Chem. 2012 Oct 12;287(42):34979-34991. doi: 10.1074/jbc.M112.374504. Epub 2012 Aug 1. J Biol Chem. 2012. PMID: 22859300 Free PMC article.

3

Open and closed conformations of the isolated transmembrane domain of death receptor 5 support a new model of activation.

Lewis AK, James ZM, McCaffrey JE, Braun AR, Karim CB, Thomas DD, Sachs JN. Lewis AK, et al. Biophys J. 2014 Mar 18;106(6):L21-4. doi: 10.1016/j.bpj.2014.01.044. Biophys J. 2014. PMID: 24655519 Free PMC article.

4

Death Receptor 5 Networks Require Membrane Cholesterol for Proper Structure and Function.

Lewis AK, Valley CC, Peery SL, Brummel B, Braun AR, Karim CB, Sachs JN. Lewis AK, et al. J Mol Biol. 2016 Dec 4;428(24 Pt A):4843-4855. doi: 10.1016/j.jmb.2016.10.001. Epub 2016 Oct 6. J Mol Biol. 2016. PMID: 27720987 Free PMC article.

5

Piecing it together: Unraveling the elusive structure-function relationship in single-pass membrane receptors.

Valley CC, Lewis AK, Sachs JN. Valley CC, et al. Among authors: lewis ak. Biochim Biophys Acta Biomembr. 2017 Sep;1859(9 Pt A):1398-1416. doi: 10.1016/j.bbamem.2017.01.016. Epub 2017 Jan 12. Biochim Biophys Acta Biomembr. 2017. PMID: 28089689 Free PMC article. Review.

6

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces death receptor 5 networks that are highly organized.

Valley CC, Lewis AK, Mudaliar DJ, Perlmutter JD, Braun AR, Karim CB, Thomas DD, Brody JR, Sachs JN. Valley CC, et al. Among authors: lewis ak. J Biol Chem. 2012 Jun 15;287(25):21265-78. doi: 10.1074/jbc.M111.306480. Epub 2012 Apr 10. J Biol Chem. 2012. PMID: 22496450 Free PMC article.

7

TNFR1 signaling is associated with backbone conformational changes of receptor dimers consistent with overactivation in the R92Q TRAPS mutant.

Lewis AK, Valley CC, Sachs JN. Lewis AK, et al. Biochemistry. 2012 Aug 21;51(33):6545-55. doi: 10.1021/bi3006626. Epub 2012 Aug 8. Biochemistry. 2012. PMID: 22799488

8

Minimal Nucleation State of α-Synuclein Is Stabilized by Dynamic Threonine-Water Networks.

Romo TD, Lewis AK, Braun AR, Grossfield A, Sachs JN. Romo TD, et al. Among authors: lewis ak. ACS Chem Neurosci. 2017 Sep 20;8(9):1859-1864. doi: 10.1021/acschemneuro.7b00171. Epub 2017 Jul 10. ACS Chem Neurosci. 2017. PMID: 28677385 Free PMC article.

9

Death Receptor 5 Activation Is Energetically Coupled to Opening of the Transmembrane Domain Dimer.

Vunnam N, Campbell-Bezat CK, Lewis AK, Sachs JN. Vunnam N, et al. Among authors: lewis ak. Biophys J. 2017 Jul 25;113(2):381-392. doi: 10.1016/j.bpj.2017.05.038. Biophys J. 2017. PMID: 28746849 Free PMC article.

10

An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors.

Lo CH, Vunnam N, Lewis AK, Chiu TL, Brummel BE, Schaaf TM, Grant BD, Bawaskar P, Thomas DD, Sachs JN. Lo CH, et al. Among authors: lewis ak. SLAS Discov. 2017 Sep;22(8):950-961. doi: 10.1177/2472555217706478. Epub 2017 May 22. SLAS Discov. 2017. PMID: 28530838 Free PMC article.

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