Tracy TS - Search Results

1

CYP2C9 Genotype-Dependent Warfarin Pharmacokinetics: Impact of CYP2C9 Genotype on R- and S-Warfarin and Their Oxidative Metabolites.

Flora DR, Rettie AE, Brundage RC, Tracy TS. Flora DR, et al. Among authors: tracy ts. J Clin Pharmacol. 2017 Mar;57(3):382-393. doi: 10.1002/jcph.813. Epub 2016 Sep 22. J Clin Pharmacol. 2017. PMID: 27539372

2

CYP2C9 genotype-dependent effects on in vitro drug-drug interactions: switching of benzbromarone effect from inhibition to activation in the CYP2C9.3 variant.

Hummel MA, Locuson CW, Gannett PM, Rock DA, Mosher CM, Rettie AE, Tracy TS. Hummel MA, et al. Among authors: tracy ts. Mol Pharmacol. 2005 Sep;68(3):644-51. doi: 10.1124/mol.105.013763. Epub 2005 Jun 13. Mol Pharmacol. 2005. PMID: 15955872

3

Differential genotype dependent inhibition of CYP2C9 in humans.

Kumar V, Brundage RC, Oetting WS, Leppik IE, Tracy TS. Kumar V, et al. Among authors: tracy ts. Drug Metab Dispos. 2008 Jul;36(7):1242-8. doi: 10.1124/dmd.108.020396. Epub 2008 Mar 31. Drug Metab Dispos. 2008. PMID: 18378563 Free PMC article. Clinical Trial.

4

Development of an in vitro system with human liver microsomes for phenotyping of CYP2C9 genetic polymorphisms with a mechanism-based inactivator.

Flora DR, Tracy TS. Flora DR, et al. Among authors: tracy ts. Drug Metab Dispos. 2012 Apr;40(4):836-42. doi: 10.1124/dmd.111.043372. Epub 2011 Dec 28. Drug Metab Dispos. 2012. PMID: 22205778 Free PMC article.

5

Pharmacokinetic Modeling of Warfarin І - Model-based Analysis of Warfarin Enantiomers with a Target Mediated Drug Disposition Model Reveals CYP2C9 Genotype-dependent Drug-drug Interactions of S-Warfarin.

Cheng S, Flora DR, Rettie AE, Brundage RC, Tracy TS. Cheng S, et al. Among authors: tracy ts. Drug Metab Dispos. 2022 Jul 7;50(9):1287-301. doi: 10.1124/dmd.122.000876. Online ahead of print. Drug Metab Dispos. 2022. PMID: 35798369 Free PMC article.

6

Polymorphic variants (CYP2C9*3 and CYP2C9*5) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles.

Tracy TS, Hutzler JM, Haining RL, Rettie AE, Hummel MA, Dickmann LJ. Tracy TS, et al. Drug Metab Dispos. 2002 Apr;30(4):385-90. doi: 10.1124/dmd.30.4.385. Drug Metab Dispos. 2002. PMID: 11901091

7

Differential activation of CYP2C9 variants by dapsone.

Hummel MA, Dickmann LJ, Rettie AE, Haining RL, Tracy TS. Hummel MA, et al. Among authors: tracy ts. Biochem Pharmacol. 2004 May 15;67(10):1831-41. doi: 10.1016/j.bcp.2004.01.017. Biochem Pharmacol. 2004. PMID: 15130760

8

Functional analysis of phenylalanine residues in the active site of cytochrome P450 2C9.

Mosher CM, Hummel MA, Tracy TS, Rettie AE. Mosher CM, et al. Among authors: tracy ts. Biochemistry. 2008 Nov 11;47(45):11725-34. doi: 10.1021/bi801231m. Epub 2008 Oct 16. Biochemistry. 2008. PMID: 18922023 Free PMC article.

9

The use of immobilized cytochrome P4502C9 in PMMA-based plug flow bioreactors for the production of drug metabolites.

Wollenberg LA, Kabulski JL, Powell MJ, Chen J, Flora DR, Tracy TS, Gannett PM. Wollenberg LA, et al. Among authors: tracy ts. Appl Biochem Biotechnol. 2014 Feb;172(3):1293-306. doi: 10.1007/s12010-013-0537-z. Epub 2013 Oct 30. Appl Biochem Biotechnol. 2014. PMID: 24166101 Free PMC article.

10

Immobilized Cytochrome P450 for Monitoring of P450-P450 Interactions and Metabolism.

Bostick CD, Hickey KM, Wollenberg LA, Flora DR, Tracy TS, Gannett PM. Bostick CD, et al. Among authors: tracy ts. Drug Metab Dispos. 2016 May;44(5):741-9. doi: 10.1124/dmd.115.067637. Epub 2016 Mar 9. Drug Metab Dispos. 2016. PMID: 26961240 Free PMC article.

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