Ledwitch KV - Search Results

1

Cooperativity between verapamil and ATP bound to the efflux transporter P-glycoprotein.

Ledwitch KV, Gibbs ME, Barnes RW, Roberts AG. Ledwitch KV, et al. Biochem Pharmacol. 2016 Oct 15;118:96-108. doi: 10.1016/j.bcp.2016.08.013. Epub 2016 Aug 13. Biochem Pharmacol. 2016. PMID: 27531061 Free PMC article.

2

Unravelling the complex drug-drug interactions of the cardiovascular drugs, verapamil and digoxin, with P-glycoprotein.

Ledwitch KV, Barnes RW, Roberts AG. Ledwitch KV, et al. Biosci Rep. 2016 Jan 28;36(2):e00309. doi: 10.1042/BSR20150317. Biosci Rep. 2016. PMID: 26823559 Free PMC article.

3

Cardiovascular Ion Channel Inhibitor Drug-Drug Interactions with P-glycoprotein.

Ledwitch KV, Roberts AG. Ledwitch KV, et al. AAPS J. 2017 Mar;19(2):409-420. doi: 10.1208/s12248-016-0023-y. Epub 2016 Dec 27. AAPS J. 2017. PMID: 28028729 Free PMC article. Review.

4

A Conformationally Gated Model of Methadone and Loperamide Transport by P-Glycoprotein.

Gibbs ME, Wilt LA, Ledwitch KV, Roberts AG. Gibbs ME, et al. Among authors: ledwitch kv. J Pharm Sci. 2018 Jul;107(7):1937-1947. doi: 10.1016/j.xphs.2018.02.019. Epub 2018 Feb 28. J Pharm Sci. 2018. PMID: 29499278 Free PMC article.

5

Boosted coupling of ATP hydrolysis to substrate transport upon cooperative estradiol-17-β-D-glucuronide binding in a Drosophila ATP binding cassette type-C transporter.

Karasik A, Ledwitch KV, Arányi T, Váradi A, Roberts A, Szeri F. Karasik A, et al. Among authors: ledwitch kv. FASEB J. 2018 Feb;32(2):669-680. doi: 10.1096/fj.201700606R. Epub 2018 Jan 4. FASEB J. 2018. PMID: 28939593 Free PMC article.

6

The role of cytochrome P450 BM3 phenylalanine-87 and threonine-268 in binding organic hydroperoxides.

Roberts AG, Katayama J, Kaspera R, Ledwitch KV, Le Trong I, Stenkamp RE, Thompson JA, Totah RA. Roberts AG, et al. Among authors: ledwitch kv. Biochim Biophys Acta. 2016 Apr;1860(4):669-77. doi: 10.1016/j.bbagen.2015.12.014. Epub 2015 Dec 23. Biochim Biophys Acta. 2016. PMID: 26723172

7

Copper ion as a delivery platform for taxanes and taxane complexes.

Manning TJ, Phillips D, Wylie G, Bythell B, Clark S, Ogburn R, Ledwitch K, Collis C, Patterson S, Lasseter L. Manning TJ, et al. Bioorg Med Chem Lett. 2014 Jan 1;24(1):371-7. doi: 10.1016/j.bmcl.2013.10.073. Epub 2013 Nov 14. Bioorg Med Chem Lett. 2014. PMID: 24269164

8

A unified structural model of the mammalian translocator protein (TSPO).

Xia Y, Ledwitch K, Kuenze G, Duran A, Li J, Sanders CR, Manning C, Meiler J. Xia Y, et al. J Biomol NMR. 2019 Jul;73(6-7):347-364. doi: 10.1007/s10858-019-00257-1. Epub 2019 Jun 26. J Biomol NMR. 2019. PMID: 31243635 Free PMC article.

9

Taxol: efficacy against oral squamous cell carcinoma.

Ledwitch K, Ogburn R, Cox J, Graham R, Fritzsche A, Gosnell D, Manning T. Ledwitch K, et al. Mini Rev Med Chem. 2013 Apr;13(4):509-21. doi: 10.2174/1389557511313040004. Mini Rev Med Chem. 2013. PMID: 23373651 Review.

10

Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia.

Aguilar JI, Cheng MH, Font J, Schwartz AC, Ledwitch K, Duran A, Mabry SJ, Belovich AN, Zhu Y, Carter AM, Shi L, Kurian MA, Fenollar-Ferrer C, Meiler J, Ryan RM, Mchaourab HS, Bahar I, Matthies HJ, Galli A. Aguilar JI, et al. Elife. 2021 May 18;10:e68039. doi: 10.7554/eLife.68039. Elife. 2021. PMID: 34002696 Free PMC article.

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