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Cyclic adenosine 3'-5'-monophosphate (cAMP) exerts proliferative and anti-proliferative effects in pituitary cells of different types by activating both cAMP-dependent protein kinase A (PKA) and exchange proteins directly activated by cAMP (Epac).
Vitali E, Peverelli E, Giardino E, Locatelli M, Lasio GB, Beck-Peccoz P, Spada A, Lania AG, Mantovani G. Vitali E, et al. Among authors: giardino e. Mol Cell Endocrinol. 2014 Mar 5;383(1-2):193-202. doi: 10.1016/j.mce.2013.12.006. Epub 2013 Dec 25. Mol Cell Endocrinol. 2014. PMID: 24373949
Somatostatin Receptor Type 2 (SSTR2) Internalization and Intracellular Trafficking in Pituitary GH-Secreting Adenomas: Role of Scaffold Proteins and Implications for Pharmacological Resistance.
Treppiedi D, Peverelli E, Giardino E, Ferrante E, Calebiro D, Spada A, Mantovani G. Treppiedi D, et al. Among authors: giardino e. Horm Metab Res. 2017 Apr;49(4):259-268. doi: 10.1055/s-0042-116025. Epub 2016 Sep 15. Horm Metab Res. 2017. PMID: 27632151 Review. No abstract available.
Dopamine receptor type 2 (DRD2) and somatostatin receptor type 2 (SSTR2) agonists are effective in inhibiting proliferation of progenitor/stem-like cells isolated from nonfunctioning pituitary tumors.
Peverelli E, Giardino E, Treppiedi D, Meregalli M, Belicchi M, Vaira V, Corbetta S, Verdelli C, Verrua E, Serban AL, Locatelli M, Carrabba G, Gaudenzi G, Malchiodi E, Cassinelli L, Lania AG, Ferrero S, Bosari S, Vitale G, Torrente Y, Spada A, Mantovani G. Peverelli E, et al. Among authors: giardino e. Int J Cancer. 2017 Apr 15;140(8):1870-1880. doi: 10.1002/ijc.30613. Epub 2017 Feb 8. Int J Cancer. 2017. PMID: 28120505
Cofilin is a cAMP effector in mediating actin cytoskeleton reorganization and steroidogenesis in mouse and human adrenocortical tumor cells.
Peverelli E, Catalano R, Giardino E, Treppiedi D, Morelli V, Ronchi CL, Vaczlavik A, Fusco N, Ferrero S, Bertherat J, Beuschlein F, Chiodini I, Arosio M, Spada A, Mantovani G. Peverelli E, et al. Among authors: giardino e. Cancer Lett. 2017 Oct 10;406:54-63. doi: 10.1016/j.canlet.2017.07.025. Epub 2017 Aug 5. Cancer Lett. 2017. PMID: 28826686 Free article.
59 results