Zhuang Y - Search Results

1

First-in-human study to assess guselkumab (anti-IL-23 mAb) pharmacokinetics/safety in healthy subjects and patients with moderate-to-severe psoriasis.

Zhuang Y, Calderon C, Marciniak SJ Jr, Bouman-Thio E, Szapary P, Yang TY, Schantz A, Davis HM, Zhou H, Xu Z. Zhuang Y, et al. Eur J Clin Pharmacol. 2016 Nov;72(11):1303-1310. doi: 10.1007/s00228-016-2110-5. Epub 2016 Aug 11. Eur J Clin Pharmacol. 2016. PMID: 27515978 Clinical Trial.

2

Subcutaneous bioavailability of golimumab at 3 different injection sites in healthy subjects.

Xu Z, Wang Q, Zhuang Y, Frederick B, Yan H, Bouman-Thio E, Marini JC, Keen M, Snead D, Davis HM, Zhou H. Xu Z, et al. Among authors: zhuang y. J Clin Pharmacol. 2010 Mar;50(3):276-84. doi: 10.1177/0091270009340782. Epub 2009 Nov 25. J Clin Pharmacol. 2010. PMID: 19940229 Clinical Trial.

3

Golimumab pharmacokinetics after repeated subcutaneous and intravenous administrations in patients with rheumatoid arthritis and the effect of concomitant methotrexate: an open-label, randomized study.

Zhuang Y, Xu Z, Frederick B, de Vries DE, Ford JA, Keen M, Doyle MK, Petty KJ, Davis HM, Zhou H. Zhuang Y, et al. Clin Ther. 2012 Jan;34(1):77-90. doi: 10.1016/j.clinthera.2011.11.015. Epub 2011 Dec 14. Clin Ther. 2012. PMID: 22169051 Clinical Trial.

4

Pharmacokinetics and safety of sirukumab following a single subcutaneous administration to healthy Japanese and Caucasian subjects.

Zhuang Y, Xu Z, de Vries DE, Wang Q, Shishido A, Comisar C, Ford JA, Keen M, Achira M, Tsukamoto Y, Petty KJ, Davis HM, Zhou H. Zhuang Y, et al. Int J Clin Pharmacol Ther. 2013 Mar;51(3):187-99. doi: 10.5414/CP201785. Int J Clin Pharmacol Ther. 2013. PMID: 23357841 Clinical Trial.

5

Pharmacokinetics and safety of golimumab in healthy Chinese subjects following a single subcutaneous administration in a randomized phase I trial.

Zhuang Y, Lyn S, Lv Y, Xu Z, Bouman-Thio E, Masterson T, Ford JA, Keen M, Petty KJ, Davis HM, Zhou H. Zhuang Y, et al. Clin Drug Investig. 2013 Nov;33(11):795-800. doi: 10.1007/s40261-013-0124-7. Clin Drug Investig. 2013. PMID: 23975656 Clinical Trial.

6

Sirukumab, a human anti-interleukin-6 monoclonal antibody: a randomised, 2-part (proof-of-concept and dose-finding), phase II study in patients with active rheumatoid arthritis despite methotrexate therapy.

Smolen JS, Weinblatt ME, Sheng S, Zhuang Y, Hsu B. Smolen JS, et al. Among authors: zhuang y. Ann Rheum Dis. 2014 Sep;73(9):1616-25. doi: 10.1136/annrheumdis-2013-205137. Epub 2014 Apr 3. Ann Rheum Dis. 2014. PMID: 24699939 Free PMC article. Clinical Trial.

7

Information contributed by meta-analysis in exposure-response modeling: application to phase 2 dose selection of guselkumab in patients with moderate-to-severe psoriasis.

Hu C, Wasfi Y, Zhuang Y, Zhou H. Hu C, et al. Among authors: zhuang y. J Pharmacokinet Pharmacodyn. 2014 Jun;41(3):239-50. doi: 10.1007/s10928-014-9360-6. Epub 2014 May 23. J Pharmacokinet Pharmacodyn. 2014. PMID: 24852042 Clinical Trial.

8

Pharmacokinetic bridging approach for developing biologics-delivery devices: a case study with a golimumab autoinjector.

Xu Z, Marciniak SJ Jr, Frederick B, Kim L, Zhuang Y, Davis HM, Zhou H. Xu Z, et al. Among authors: zhuang y. Clin Ther. 2015 Feb 1;37(2):427-38. doi: 10.1016/j.clinthera.2014.09.012. Epub 2014 Oct 29. Clin Ther. 2015. PMID: 25438720 Clinical Trial.

9

Evaluation of disease-mediated therapeutic protein-drug interactions between an anti-interleukin-6 monoclonal antibody (sirukumab) and cytochrome P450 activities in a phase 1 study in patients with rheumatoid arthritis using a cocktail approach.

Zhuang Y, de Vries DE, Xu Z, Marciniak SJ Jr, Chen D, Leon F, Davis HM, Zhou H. Zhuang Y, et al. J Clin Pharmacol. 2015 Dec;55(12):1386-94. doi: 10.1002/jcph.561. Epub 2015 Jul 29. J Clin Pharmacol. 2015. PMID: 26054042 Clinical Trial.

10

Development of a Physiologically Based Pharmacokinetic Model to Predict Disease-Mediated Therapeutic Protein-Drug Interactions: Modulation of Multiple Cytochrome P450 Enzymes by Interleukin-6.

Jiang X, Zhuang Y, Xu Z, Wang W, Zhou H. Jiang X, et al. Among authors: zhuang y. AAPS J. 2016 May;18(3):767-76. doi: 10.1208/s12248-016-9890-5. Epub 2016 Mar 9. AAPS J. 2016. PMID: 26961818 Free PMC article.

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