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Cannabinoid-induced depression of synaptic transmission is switched to stimulation when dopaminergic tone is increased in the globus pallidus of the rodent.
Caballero-Florán RN, Conde-Rojas I, Oviedo Chávez A, Cortes-Calleja H, Lopez-Santiago LF, Isom LL, Aceves J, Erlij D, Florán B. Caballero-Florán RN, et al. Neuropharmacology. 2016 Nov;110(Pt A):407-418. doi: 10.1016/j.neuropharm.2016.08.002. Epub 2016 Aug 6. Neuropharmacology. 2016. PMID: 27506997
Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.
Lopez-Santiago LF, Meadows LS, Ernst SJ, Chen C, Malhotra JD, McEwen DP, Speelman A, Noebels JL, Maier SK, Lopatin AN, Isom LL. Lopez-Santiago LF, et al. J Mol Cell Cardiol. 2007 Nov;43(5):636-47. doi: 10.1016/j.yjmcc.2007.07.062. Epub 2007 Aug 10. J Mol Cell Cardiol. 2007. PMID: 17884088 Free PMC article.
A functional null mutation of SCN1B in a patient with Dravet syndrome.
Patino GA, Claes LR, Lopez-Santiago LF, Slat EA, Dondeti RS, Chen C, O'Malley HA, Gray CB, Miyazaki H, Nukina N, Oyama F, De Jonghe P, Isom LL. Patino GA, et al. J Neurosci. 2009 Aug 26;29(34):10764-78. doi: 10.1523/JNEUROSCI.2475-09.2009. J Neurosci. 2009. PMID: 19710327 Free PMC article.
Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism.
Liu Y, Lopez-Santiago LF, Yuan Y, Jones JM, Zhang H, O'Malley HA, Patino GA, O'Brien JE, Rusconi R, Gupta A, Thompson RC, Natowicz MR, Meisler MH, Isom LL, Parent JM. Liu Y, et al. Ann Neurol. 2013 Jul;74(1):128-39. doi: 10.1002/ana.23897. Epub 2013 Jul 2. Ann Neurol. 2013. PMID: 23821540 Free PMC article.
27 results