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An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.
Atapattu L, Saha N, Chheang C, Eissman MF, Xu K, Vail ME, Hii L, Llerena C, Liu Z, Horvay K, Abud HE, Kusebauch U, Moritz RL, Ding BS, Cao Z, Rafii S, Ernst M, Scott AM, Nikolov DB, Lackmann M, Janes PW. Atapattu L, et al. Among authors: lackmann m. J Exp Med. 2016 Aug 22;213(9):1741-57. doi: 10.1084/jem.20151095. Epub 2016 Aug 8. J Exp Med. 2016. PMID: 27503072 Free PMC article.
Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors.
Janes PW, Griesshaber B, Atapattu L, Nievergall E, Hii LL, Mensinga A, Chheang C, Day BW, Boyd AW, Bastiaens PI, Jørgensen C, Pawson T, Lackmann M. Janes PW, et al. Among authors: lackmann m. J Cell Biol. 2011 Dec 12;195(6):1033-45. doi: 10.1083/jcb.201104037. Epub 2011 Dec 5. J Cell Biol. 2011. PMID: 22144690 Free PMC article.
Targeting EphA3 inhibits cancer growth by disrupting the tumor stromal microenvironment.
Vail ME, Murone C, Tan A, Hii L, Abebe D, Janes PW, Lee FT, Baer M, Palath V, Bebbington C, Yarranton G, Llerena C, Garic S, Abramson D, Cartwright G, Scott AM, Lackmann M. Vail ME, et al. Among authors: lackmann m. Cancer Res. 2014 Aug 15;74(16):4470-81. doi: 10.1158/0008-5472.CAN-14-0218. Cancer Res. 2014. PMID: 25125683
The role of proteases in regulating Eph/ephrin signaling.
Atapattu L, Lackmann M, Janes PW. Atapattu L, et al. Among authors: lackmann m. Cell Adh Migr. 2014;8(4):294-307. doi: 10.4161/19336918.2014.970026. Cell Adh Migr. 2014. PMID: 25482632 Free PMC article. Review.
Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10.
Janes PW, Wimmer-Kleikamp SH, Frangakis AS, Treble K, Griesshaber B, Sabet O, Grabenbauer M, Ting AY, Saftig P, Bastiaens PI, Lackmann M. Janes PW, et al. Among authors: lackmann m. PLoS Biol. 2009 Oct;7(10):e1000215. doi: 10.1371/journal.pbio.1000215. Epub 2009 Oct 13. PLoS Biol. 2009. PMID: 19823572 Free PMC article.
65 results