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Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors.
Cooper IR, McCarroll AJ, McGarry D, Kirkham J, Pichowicz M, Walker R, Warrilow C, Salisbury AM, Savage VJ, Moyo E, Forward H, Cheung J, Metzger R, Gault Z, Nelson G, Hughes D, Cao S, Maclean J, Charrier C, Craighead M, Best S, Stokes NR, Ratcliffe AJ. Cooper IR, et al. Among authors: hughes d. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4179-83. doi: 10.1016/j.bmcl.2016.07.061. Epub 2016 Jul 28. Bioorg Med Chem Lett. 2016. PMID: 27499455 Free article.
Can phylogenetic type predict resistance development?
Nazir H, Cao S, Hasan F, Hughes D. Nazir H, et al. Among authors: hughes d. J Antimicrob Chemother. 2011 Apr;66(4):778-87. doi: 10.1093/jac/dkq505. Epub 2011 Jan 22. J Antimicrob Chemother. 2011. PMID: 21393154
Selection of resistant bacteria at very low antibiotic concentrations.
Gullberg E, Cao S, Berg OG, Ilbäck C, Sandegren L, Hughes D, Andersson DI. Gullberg E, et al. Among authors: hughes d. PLoS Pathog. 2011 Jul;7(7):e1002158. doi: 10.1371/journal.ppat.1002158. Epub 2011 Jul 21. PLoS Pathog. 2011. PMID: 21811410 Free PMC article.
Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB).
De Rosa M, Lu L, Zamaratski E, Szałaj N, Cao S, Wadensten H, Lenhammar L, Gising J, Roos AK, Huseby DL, Larsson R, Andrén PE, Hughes D, Brandt P, Mowbray SL, Karlén A. De Rosa M, et al. Among authors: hughes d. Bioorg Med Chem. 2017 Feb 1;25(3):897-911. doi: 10.1016/j.bmc.2016.12.003. Epub 2016 Dec 7. Bioorg Med Chem. 2017. PMID: 28038943 Free article.
3,994 results