Lefkowitz RJ - Search Results

1

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.

Thomsen ARB, Plouffe B, Cahill TJ 3rd, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJ. Thomsen ARB, et al. Among authors: lefkowitz rj. Cell. 2016 Aug 11;166(4):907-919. doi: 10.1016/j.cell.2016.07.004. Epub 2016 Aug 4. Cell. 2016. PMID: 27499021 Free PMC article.

2

Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor.

Hausdorff WP, Lohse MJ, Bouvier M, Liggett SB, Caron MG, Lefkowitz RJ. Hausdorff WP, et al. Among authors: lefkowitz rj. Symp Soc Exp Biol. 1990;44:225-40. Symp Soc Exp Biol. 1990. PMID: 1983369

3

Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.

Valiquette M, Bonin H, Hnatowich M, Caron MG, Lefkowitz RJ, Bouvier M. Valiquette M, et al. Among authors: lefkowitz rj. Proc Natl Acad Sci U S A. 1990 Jul;87(13):5089-93. doi: 10.1073/pnas.87.13.5089. Proc Natl Acad Sci U S A. 1990. PMID: 2164220 Free PMC article.

4

Mechanisms involved in adrenergic receptor desensitization.

Collins S, Bouvier M, Lohse MJ, Benovic JL, Caron MG, Lefkowitz RJ. Collins S, et al. Among authors: lefkowitz rj. Biochem Soc Trans. 1990 Aug;18(4):541-4. doi: 10.1042/bst0180541. Biochem Soc Trans. 1990. PMID: 2177406 Review. No abstract available.

5

cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.

Collins S, Bouvier M, Bolanowski MA, Caron MG, Lefkowitz RJ. Collins S, et al. Among authors: lefkowitz rj. Proc Natl Acad Sci U S A. 1989 Jul;86(13):4853-7. doi: 10.1073/pnas.86.13.4853. Proc Natl Acad Sci U S A. 1989. PMID: 2472635 Free PMC article.

6

Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level.

Bouvier M, Collins S, O'Dowd BF, Campbell PT, de Blasi A, Kobilka BK, MacGregor C, Irons GP, Caron MG, Lefkowitz RJ. Bouvier M, et al. Among authors: lefkowitz rj. J Biol Chem. 1989 Oct 5;264(28):16786-92. J Biol Chem. 1989. PMID: 2476447 Free article.

7

Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.

O'Dowd BF, Hnatowich M, Caron MG, Lefkowitz RJ, Bouvier M. O'Dowd BF, et al. Among authors: lefkowitz rj. J Biol Chem. 1989 May 5;264(13):7564-9. J Biol Chem. 1989. PMID: 2540197 Free article.

8

Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization.

Hausdorff WP, Bouvier M, O'Dowd BF, Irons GP, Caron MG, Lefkowitz RJ. Hausdorff WP, et al. Among authors: lefkowitz rj. J Biol Chem. 1989 Jul 25;264(21):12657-65. J Biol Chem. 1989. PMID: 2545714 Free article.

9

Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites.

Liggett SB, Bouvier M, Hausdorff WP, O'Dowd B, Caron MG, Lefkowitz RJ. Liggett SB, et al. Among authors: lefkowitz rj. Mol Pharmacol. 1989 Oct;36(4):641-6. Mol Pharmacol. 1989. PMID: 2554115

10

Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization.

Liggett SB, Bouvier M, O'Dowd BF, Caron MG, Lefkowitz RJ, DeBlasi A. Liggett SB, et al. Among authors: lefkowitz rj. Biochem Biophys Res Commun. 1989 Nov 30;165(1):257-63. doi: 10.1016/0006-291x(89)91063-2. Biochem Biophys Res Commun. 1989. PMID: 2556136

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