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Page 1
The aged lymphoid tissue environment fails to support naïve T cell homeostasis.
Becklund BR, Purton JF, Ramsey C, Favre S, Vogt TK, Martin CE, Spasova DS, Sarkisyan G, LeRoy E, Tan JT, Wahlus H, Bondi-Boyd B, Luther SA, Surh CD. Becklund BR, et al. Among authors: spasova ds. Sci Rep. 2016 Aug 2;6:30842. doi: 10.1038/srep30842. Sci Rep. 2016. PMID: 27480406 Free PMC article.
Homeostatic proliferation of mature T cells.
Martin CE, Frimpong-Boateng K, Spasova DS, Stone JC, Surh CD. Martin CE, et al. Among authors: spasova ds. Methods Mol Biol. 2013;979:81-106. doi: 10.1007/978-1-62703-290-2_9. Methods Mol Biol. 2013. PMID: 23397391
Self-Replicating RNAs Drive Protective Anti-tumor T Cell Responses to Neoantigen Vaccine Targets in a Combinatorial Approach.
Maine CJ, Richard G, Spasova DS, Miyake-Stoner SJ, Sparks J, Moise L, Sullivan RP, Garijo O, Choz M, Crouse JM, Aguilar A, Olesiuk MD, Lyons K, Salvador K, Blomgren M, DeHart JL, Kamrud KI, Berdugo G, De Groot AS, Wang NS, Aliahmad P. Maine CJ, et al. Among authors: spasova ds. Mol Ther. 2021 Mar 3;29(3):1186-1198. doi: 10.1016/j.ymthe.2020.11.027. Epub 2020 Dec 3. Mol Ther. 2021. PMID: 33278563 Free PMC article.
CD8+ T cells mediate protection against Zika virus induced by an NS3-based vaccine.
Elong Ngono A, Syed T, Nguyen AV, Regla-Nava JA, Susantono M, Spasova D, Aguilar A, West M, Sparks J, Gonzalez A, Branche E, DeHart JL, Vega JB, Karmali PP, Chivukula P, Kamrud K, Aliahmad P, Wang N, Shresta S. Elong Ngono A, et al. Sci Adv. 2020 Nov 4;6(45):eabb2154. doi: 10.1126/sciadv.abb2154. Print 2020 Nov. Sci Adv. 2020. PMID: 33148638 Free PMC article.
Safety and immunogenicity of an optimized self-replicating RNA platform for low dose or single dose vaccine applications: a randomized, open label Phase I study in healthy volunteers.
Maine CJ, Miyake-Stoner SJ, Spasova DS, Picarda G, Chou AC, Brand ED, Olesiuk MD, Domingo CC, Little HJ, Goodman TT, Posy JL, Gonzalez J, Bayone TL, Sparks J, Gary EN, Xiang Z, Tursi NJ, Hojecki CE, Ertl HCJ, Weiner DB, Casmil IC, Blakney AK, Essink B, Somodevilla G, Wang NS, Geall AJ, Goldberg Z, Aliahmad P. Maine CJ, et al. Among authors: spasova ds. Nat Commun. 2025 Jan 7;16(1):456. doi: 10.1038/s41467-025-55843-9. Nat Commun. 2025. PMID: 39774967 Free PMC article. Clinical Trial.