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2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.
Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS. Sulkowski PL, et al. Among authors: bindra rs. Sci Transl Med. 2017 Feb 1;9(375):eaal2463. doi: 10.1126/scitranslmed.aal2463. Sci Transl Med. 2017. PMID: 28148839 Free PMC article.
DNA polymerase beta participates in DNA End-joining.
Ray S, Breuer G, DeVeaux M, Zelterman D, Bindra R, Sweasy JB. Ray S, et al. Nucleic Acids Res. 2018 Jan 9;46(1):242-255. doi: 10.1093/nar/gkx1147. Nucleic Acids Res. 2018. PMID: 29161447 Free PMC article.
Identification of novel radiosensitizers in a high-throughput, cell-based screen for DSB repair inhibitors.
Goglia AG, Delsite R, Luz AN, Shahbazian D, Salem AF, Sundaram RK, Chiaravalli J, Hendrikx PJ, Wilshire JA, Jasin M, Kluger HM, Glickman JF, Powell SN, Bindra RS. Goglia AG, et al. Among authors: bindra rs. Mol Cancer Ther. 2015 Feb;14(2):326-42. doi: 10.1158/1535-7163.MCT-14-0765. Epub 2014 Dec 15. Mol Cancer Ther. 2015. PMID: 25512618 Free PMC article.
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
Daddacha W, Koyen AE, Bastien AJ, Head PE, Dhere VR, Nabeta GN, Connolly EC, Werner E, Madden MZ, Daly MB, Minten EV, Whelan DR, Schlafstein AJ, Zhang H, Anand R, Doronio C, Withers AE, Shepard C, Sundaram RK, Deng X, Dynan WS, Wang Y, Bindra RS, Cejka P, Rothenberg E, Doetsch PW, Kim B, Yu DS. Daddacha W, et al. Among authors: bindra rs. Cell Rep. 2017 Aug 22;20(8):1921-1935. doi: 10.1016/j.celrep.2017.08.008. Cell Rep. 2017. PMID: 28834754 Free PMC article.
115 results