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A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency.
Jankipersadsing SA, Hadizadeh F, Bonder MJ, Tigchelaar EF, Deelen P, Fu J, Andreasson A, Agreus L, Walter S, Wijmenga C, Hysi P, D'Amato M, Zhernakova A. Jankipersadsing SA, et al. Among authors: tigchelaar ef. Gut. 2017 Apr;66(4):756-758. doi: 10.1136/gutjnl-2016-312398. Epub 2016 Jul 29. Gut. 2017. PMID: 27473416 Free PMC article. No abstract available.
Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels.
Kumar V, Gutierrez-Achury J, Kanduri K, Almeida R, Hrdlickova B, Zhernakova DV, Westra HJ, Karjalainen J, Ricaño-Ponce I, Li Y, Stachurska A, Tigchelaar EF, Abdulahad WH, Lähdesmäki H, Hofker MH, Zhernakova A, Franke L, Lahesmaa R, Wijmenga C, Withoff S. Kumar V, et al. Among authors: tigchelaar ef. Hum Mol Genet. 2015 Jan 15;24(2):397-409. doi: 10.1093/hmg/ddu453. Epub 2014 Sep 4. Hum Mol Genet. 2015. PMID: 25190711
Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations.
Shah S, Bonder MJ, Marioni RE, Zhu Z, McRae AF, Zhernakova A, Harris SE, Liewald D, Henders AK, Mendelson MM, Liu C, Joehanes R, Liang L; BIOS Consortium; Levy D, Martin NG, Starr JM, Wijmenga C, Wray NR, Yang J, Montgomery GW, Franke L, Deary IJ, Visscher PM. Shah S, et al. Am J Hum Genet. 2015 Jul 2;97(1):75-85. doi: 10.1016/j.ajhg.2015.05.014. Epub 2015 Jun 25. Am J Hum Genet. 2015. PMID: 26119815 Free PMC article.
Gut microbiota composition associated with stool consistency.
Tigchelaar EF, Bonder MJ, Jankipersadsing SA, Fu J, Wijmenga C, Zhernakova A. Tigchelaar EF, et al. Gut. 2016 Mar;65(3):540-2. doi: 10.1136/gutjnl-2015-310328. Epub 2015 Aug 14. Gut. 2016. PMID: 26276682 No abstract available.
Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics.
Tigchelaar EF, Zhernakova A, Dekens JA, Hermes G, Baranska A, Mujagic Z, Swertz MA, Muñoz AM, Deelen P, Cénit MC, Franke L, Scholtens S, Stolk RP, Wijmenga C, Feskens EJ. Tigchelaar EF, et al. BMJ Open. 2015 Aug 28;5(8):e006772. doi: 10.1136/bmjopen-2014-006772. BMJ Open. 2015. PMID: 26319774 Free PMC article.
The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids.
Fu J, Bonder MJ, Cenit MC, Tigchelaar EF, Maatman A, Dekens JA, Brandsma E, Marczynska J, Imhann F, Weersma RK, Franke L, Poon TW, Xavier RJ, Gevers D, Hofker MH, Wijmenga C, Zhernakova A. Fu J, et al. Among authors: tigchelaar ef. Circ Res. 2015 Oct 9;117(9):817-24. doi: 10.1161/CIRCRESAHA.115.306807. Epub 2015 Sep 10. Circ Res. 2015. PMID: 26358192 Free PMC article.
Proton pump inhibitors affect the gut microbiome.
Imhann F, Bonder MJ, Vich Vila A, Fu J, Mujagic Z, Vork L, Tigchelaar EF, Jankipersadsing SA, Cenit MC, Harmsen HJ, Dijkstra G, Franke L, Xavier RJ, Jonkers D, Wijmenga C, Weersma RK, Zhernakova A. Imhann F, et al. Among authors: tigchelaar ef. Gut. 2016 May;65(5):740-8. doi: 10.1136/gutjnl-2015-310376. Epub 2015 Dec 9. Gut. 2016. PMID: 26657899 Free PMC article.
Tobacco smoking is associated with DNA methylation of diabetes susceptibility genes.
Ligthart S, Steenaard RV, Peters MJ, van Meurs JB, Sijbrands EJ, Uitterlinden AG, Bonder MJ; BIOS consortium; Hofman A, Franco OH, Dehghan A. Ligthart S, et al. Diabetologia. 2016 May;59(5):998-1006. doi: 10.1007/s00125-016-3872-0. Epub 2016 Jan 29. Diabetologia. 2016. PMID: 26825526 Free PMC article.
53 results