Chang WC - Search Results

1

Mechanistic Investigation of a Non-Heme Iron Enzyme Catalyzed Epoxidation in (-)-4'-Methoxycyclopenin Biosynthesis.

Chang WC, Li J, Lee JL, Cronican AA, Guo Y. Chang WC, et al. J Am Chem Soc. 2016 Aug 24;138(33):10390-3. doi: 10.1021/jacs.6b05400. Epub 2016 Aug 11. J Am Chem Soc. 2016. PMID: 27442345

2

Evidence for radical-mediated catalysis by HppE: a study using cyclopropyl and methylenecyclopropyl substrate analogues.

Huang H, Chang WC, Pai PJ, Romo A, Mansoorabadi SO, Russell DH, Liu HW. Huang H, et al. Among authors: chang wc. J Am Chem Soc. 2012 Oct 3;134(39):16171-4. doi: 10.1021/ja3078126. Epub 2012 Sep 24. J Am Chem Soc. 2012. PMID: 23006053 Free PMC article.

3

Reaction of HppE with substrate analogues: evidence for carbon-phosphorus bond cleavage by a carbocation rearrangement.

Chang WC, Mansoorabadi SO, Liu HW. Chang WC, et al. J Am Chem Soc. 2013 Jun 5;135(22):8153-6. doi: 10.1021/ja403441x. Epub 2013 May 23. J Am Chem Soc. 2013. PMID: 23672451 Free PMC article.

4

Substrate-triggered addition of dioxygen to the diferrous cofactor of aldehyde-deformylating oxygenase to form a diferric-peroxide intermediate.

Pandelia ME, Li N, Nørgaard H, Warui DM, Rajakovich LJ, Chang WC, Booker SJ, Krebs C, Bollinger JM Jr. Pandelia ME, et al. Among authors: chang wc. J Am Chem Soc. 2013 Oct 23;135(42):15801-12. doi: 10.1021/ja405047b. Epub 2013 Oct 9. J Am Chem Soc. 2013. PMID: 23987523 Free PMC article.

5

Evidence that the fosfomycin-producing epoxidase, HppE, is a non-heme-iron peroxidase.

Wang C, Chang WC, Guo Y, Huang H, Peck SC, Pandelia ME, Lin GM, Liu HW, Krebs C, Bollinger JM Jr. Wang C, et al. Among authors: chang wc. Science. 2013 Nov 22;342(6161):991-5. doi: 10.1126/science.1240373. Epub 2013 Oct 10. Science. 2013. PMID: 24114783 Free PMC article.

6

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase.

Matthews ML, Chang WC, Layne AP, Miles LA, Krebs C, Bollinger JM Jr. Matthews ML, et al. Among authors: chang wc. Nat Chem Biol. 2014 Mar;10(3):209-15. doi: 10.1038/nchembio.1438. Epub 2014 Jan 26. Nat Chem Biol. 2014. PMID: 24463698 Free PMC article.

7

Mechanistic consequences of chiral radical clock probes: analysis of the mononuclear non-heme iron enzyme HppE with 2-hydroxy-3-methylenecyclopropyl radical clock substrates.

Huang H, Chang WC, Lin GM, Romo A, Pai PJ, Russell WK, Russell DH, Liu HW. Huang H, et al. Among authors: chang wc. J Am Chem Soc. 2014 Feb 26;136(8):2944-7. doi: 10.1021/ja4100035. Epub 2014 Feb 13. J Am Chem Soc. 2014. PMID: 24512048 Free PMC article.

8

Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics.

Chang WC, Guo Y, Wang C, Butch SE, Rosenzweig AC, Boal AK, Krebs C, Bollinger JM Jr. Chang WC, et al. Science. 2014 Mar 7;343(6175):1140-4. doi: 10.1126/science.1248000. Science. 2014. PMID: 24604200 Free PMC article.

9

Experimental Correlation of Substrate Position with Reaction Outcome in the Aliphatic Halogenase, SyrB2.

Martinie RJ, Livada J, Chang WC, Green MT, Krebs C, Bollinger JM Jr, Silakov A. Martinie RJ, et al. Among authors: chang wc. J Am Chem Soc. 2015 Jun 3;137(21):6912-9. doi: 10.1021/jacs.5b03370. Epub 2015 May 19. J Am Chem Soc. 2015. PMID: 25965587 Free PMC article.

10

Rapid Reduction of the Diferric-Peroxyhemiacetal Intermediate in Aldehyde-Deformylating Oxygenase by a Cyanobacterial Ferredoxin: Evidence for a Free-Radical Mechanism.

Rajakovich LJ, Nørgaard H, Warui DM, Chang WC, Li N, Booker SJ, Krebs C, Bollinger JM Jr, Pandelia ME. Rajakovich LJ, et al. Among authors: chang wc. J Am Chem Soc. 2015 Sep 16;137(36):11695-709. doi: 10.1021/jacs.5b06345. Epub 2015 Sep 2. J Am Chem Soc. 2015. PMID: 26284355

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