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Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.
Pablos I, Machado Y, de Jesus HCR, Mohamud Y, Kappelhoff R, Lindskog C, Vlok M, Bell PA, Butler GS, Grin PM, Cao QT, Nguyen JP, Solis N, Abbina S, Rut W, Vederas JC, Szekely L, Szakos A, Drag M, Kizhakkedathu JN, Mossman K, Hirota JA, Jan E, Luo H, Banerjee A, Overall CM. Pablos I, et al. Among authors: grin pm. Cell Rep. 2021 Oct 26;37(4):109892. doi: 10.1016/j.celrep.2021.109892. Epub 2021 Oct 9. Cell Rep. 2021. PMID: 34672947 Free PMC article.
SARS-CoV-2 3CLpro (main protease) regulates caspase activation of gasdermin-D/E pores leading to secretion and extracellular activity of 3CLpro.
Grin PM, Baid K, de Jesus HCR, Kozarac N, Bell PA, Jiang SZ, Kappelhoff R, Butler GS, Leborgne NGF, Pan C, Pablos I, Machado Y, Vederas JC, Kim H, Benarafa C, Banerjee A, Overall CM. Grin PM, et al. Cell Rep. 2024 Dec 24;43(12):115080. doi: 10.1016/j.celrep.2024.115080. Epub 2024 Dec 12. Cell Rep. 2024. PMID: 39673710 Free article.
Optimization of quenched fluorescent peptide substrates of SARS-CoV-2 3CLpro main protease (Mpro) from proteomic identification of P6-P6' active site specificity.
Cesar Ramos de Jesus H, Solis N, Machado Y, Pablos I, Bell PA, Kappelhoff R, Grin PM, Sorgi CA, Butler GS, Overall CM. Cesar Ramos de Jesus H, et al. Among authors: grin pm. J Virol. 2024 Jun 13;98(6):e0004924. doi: 10.1128/jvi.00049-24. Epub 2024 May 14. J Virol. 2024. PMID: 38742901 Free PMC article.
11 results